Synthesis of chitosan derivative with diethyldithiocarbamate and its antifungal activity.
Synthesis of chitosan derivative with diethyldithiocarbamate and its antifungal activity.
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DOI：
10.1016/j.ijbiomac.2014.01.072
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发表时间：
2014-04
影响因子：
8.2
通讯作者：
Yukun Qin;R. Xing;Song Liu;Kecheng Li;Linfeng Hu;Huahua Yu;Xiaolin Chen;Pengcheng Li
中科院分区：
文献类型：
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作者：
Yukun Qin;R. Xing;Song Liu;Kecheng Li;Linfeng Hu;Huahua Yu;Xiaolin Chen;Pengcheng Li
目的是寻找与壳聚糖相比具有更强抗真菌性能的新型壳聚糖衍生物。对二硫代氨基甲酸二乙酯壳聚糖(EtDTCCS)进行了研究，并对其结构进行了鉴定。测定了乙二胺四乙酸二乙酯在0.25、0.5和1.0 mg/m L浓度下对链格孢菌(Alternaria Porri(A.Porri))、球孢霉(Gloeosporium Theae SinenssMiyake)和立枯丝核菌(Stemphy Lium SolaniWeber)的抑菌活性。与普通壳聚糖相比，EtDTCCS具有更好的抑制效果，抑制指数为93.2%。毒力为1.0 mg/m L，比多酚(82.5%)还要强。据推测，这类衍生物可能会在治疗各种威胁作物的疾病方面找到潜在的应用。
With an aim to discover novel chitosan derivatives with enhanced antifungal properties compared with chitosan. Diethyl dithiocarbamate chitosan (EtDTCCS) was investigated and its structure was well identified. The antifungal activity of EtDTCCS againstAlternaria porri(A. porri),Gloeosporium theae sinensisMiyake (G. theae sinensis), andStemphylium solaniWeber (S. solani) was tested at 0.25, 0.5, and 1.0 mg/mL, respectively. Compared with plain chitosan, EtDTCCS shows better inhibitory effect with 93.2% inhibitory index onG. theae sinensisat 1.0 mg/mL, even stronger than for polyoxin (82.5%). It was inferred derivatives of this kind may find potential applications for the treatment of various crop-threatening diseases.