BRAIN ACETYLCHOLINE SYNTHESIS DECLINES WITH SENESCENCE
BRAIN ACETYLCHOLINE SYNTHESIS DECLINES WITH SENESCENCE
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DOI：
10.1126/science.7256270
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
JENDEN, DJ
中科院分区：
文献类型：
--
作者：
GIBSON, GE;PETERSON, C;JENDEN, DJ
C57 BL和BALB/c两个品系的衰老小鼠全脑乙酰胆碱合成减少。[U-14 C]葡萄糖掺入乙酰胆碱在两种菌株中均减少40 ± 10%。10个月内4%。老年小鼠和58 .+-. 30个月内9%。老年小鼠与3 mo.老了在10个月和30个月内，[2 H4]胆碱与乙酰胆碱的结合下降了60%和73%。老鼠会分别胆碱能系统的缺陷可能导致大脑功能障碍，使衰老复杂化。
The synthesis of whole brain acetylcholine is reduced in 2 strains (C57BL and BALB/c) of senescent mice. The incorporation of [U-14C]glucose into acetylcholine decreased in both strains by 40 .+-. 4 percent in 10-mo.-old mice and by 58 .+-. 9 percent in 30-mo. old mice compared with mice 3 mo. old. The incorporation of [2H4]choline into acetylcholine declined 60 and 73 percent in 10 and 30-mo.-old mice, respectively. Deficits in the cholinergic system may contribute to brain dysfunctions that complicate senescence.