Effects of repeated oral methamphetamine administration in humans
Effects of repeated oral methamphetamine administration in humans
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DOI：
10.1007/s002130100727
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发表时间：
2001-06-01
影响因子：
3.4
通讯作者：
Fischman, MW
中科院分区：
文献类型：
--
作者：
Comer, SD;Hart, CL;Fischman, MW
理由：尽管在过去几年中甲基苯丙胺的使用有所增加，但很少有研究评估人类反复服用甲基苯丙胺的影响。目的：由于甲基苯丙胺经常以反复使用的模式服用，然后是一段时间的戒断，本研究试图评估人类反复服用甲基苯丙胺的影响。假设是对甲基苯丙胺的影响会产生耐受性。方法：7名正常、健康的志愿者参加了为期15天的住院研究。参与者在整个实验日重复完成主观效应问卷和精神运动表现任务。分别于第4-6天和第10-12天口服甲基苯丙胺（BID 5、10 mg）；在其他所有研究日给予安慰剂。结果：相对于安慰剂基线，只有两个“积极”的主观评分（“我感觉药物效果很好”和“我感觉很兴奋”）显著升高，并且仅在甲基苯丙胺给药的第一天。相比之下，许多“负面”评级，包括“我觉得……”在服用甲基苯丙胺的第3天，“不良药效”、“头晕”和“流感样症状”加重。与基线相比，服用甲基苯丙胺后总热量摄入减少，睡眠中断。结论：慢性给药改变了甲基苯丙胺积极主观作用的模式，反复给药后出现耐受性或效果下降。相比之下，甲基苯丙胺的负面主观影响随着时间的推移而增加。这些结果表明，在正常志愿者人群中，口服甲基苯丙胺的滥用可能性相对较低。
Rationale: Although methamphetamine use has increased over the past several years, few studies have evaluated the effects of repeated methamphetamine administration in humans. Objectives: Because methamphetamine is often taken in a pattern of repeated use followed by a period of abstinence, the present study sought to evaluate the effects of repeated methamphetamine administration in humans. The hypothesis was that tolerance would develop to methamphetamine's effects. Methods: Seven normal, healthy volunteers participated in a 15-day residential study. Participants completed subjective-effects questionnaires and psychomotor performance tasks repeatedly throughout the experimental day. Oral methamphetamine (5, 10 mg BID) was administered on days 4-6 and 10-12; placebo was administered on all other study days. Results: Relative to placebo baseline, only two "positive" subjective ratings ("I feel a good drug effect" and "I feel high") were significantly elevated, and only on the Ist day of methamphetamine administration. In contrast, numerous "negative" ratings, including "I feel..." "a bad drug effect," "dizzy," and "flu-like symptoms" were elevated on the 3rd day of methamphetamine administration. Total caloric intake decreased and sleep was disrupted after methamphetamine administration, relative to baseline. Conclusions: The pattern of methamphetamine's positive subjective effects were altered with chronic administration such that tolerance, or a decreased effect, occurred after repeated administration. In contrast, methamphetamine's negative subjective effects increased over days. These results suggest that in this population of normal volunteers, the abuse liability of oral methamphetamine is relatively low.