Transcription factors and neural stem cell self-renewal, growth and differentiation
Transcription factors and neural stem cell self-renewal, growth and differentiation
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DOI：
10.4161/cam.3.4.8803
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Yu, Yuan Hong
中科院分区：
文献类型：
--
作者：
Ahmed, Sohail;Gan, HuiTheng;Yu, Yuan Hong
中枢神经系统(CNS)是一个由相互连接和相互通信的细胞组成的大型网络，这些细胞形成了功能电路。中枢神经系统的疾病和损伤是医疗保健格局的突出特征。有一种迫切的、尚未得到满足的需求，即为中枢神经系统疾病/损伤制定治疗方案。为了增加我们对中枢神经系统的了解，我们需要建立实验上容易处理的细胞模型。神经干细胞(NSCs)是在胚胎发育过程中产生中枢神经系统的细胞，已被鉴定并在体外繁殖。为了发展神经干细胞作为中枢神经系统的细胞模型，我们需要更多地了解它们的遗传学和细胞生物学。特别是，我们需要界定自我更新、扩散和分化的机制--即NSC行为。通过绘制转录因子的调控网络来分析胚胎干细胞的多能性已被证明是了解胚胎发育的有力途径。在这里，我们讨论转录因子在NSC行为中的作用。
The central nervous system (CNS) is a large network of interconnecting and intercommunicating cells that form functional circuits. Disease and injury of the CNS are prominent features of the healthcare landscape. There is an urgent unmet need to generate therapeutic solutions for CNS disease/injury. To increase our understanding of the CNS we need to generate cellular models that are experimentally tractable. Neural stem cells (NSCs), cells that generate the CNS during embryonic development, have been identified and propagated in vitro. To develop NSCs as a cellular model for the CNS we need to understand more about their genetics and cell biology. In particular, we need to define the mechanisms of self-renewal, proliferation and differentiation-i.e. NSC behavior. The analysis of pluripotency of embryonic stem cells through mapping regulatory networks of transcription factors has proven to be a powerful approach to understanding embryonic development. Here, we discuss the role of transcription factors in NSC behavior.