Fabrication of chelate-setting α-tricalcium phosphate cement using sodium citrate and sodium alginate as mixing solution and its in vivo osteoconductivity
Fabrication of chelate-setting α-tricalcium phosphate cement using sodium citrate and sodium alginate as mixing solution and its in vivo osteoconductivity
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柠檬酸钠和海藻酸钠混合液螯合α-磷酸三钙骨水泥的制备及其体内骨传导性
DOI：
10.1002/jbm.b.34028
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
M. Aizawa
中科院分区：
文献类型：
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作者：
T. Konishi;PN. Lim;M. Honda;M. Nagaya;H. Nagashima;ES. Thian;M. Aizawa
可模塑和可注射的磷酸钙骨水泥（CPC）是骨置换应用的候选材料。在本研究中，我们研究了海藻酸钠和柠檬酸钠添加剂的CPC的液相，在改善其处理性能以及机械强度的有效性。与不含添加剂的CPC相比，这些添加剂的使用显著增强了处理性能，这是由于柠檬酸根离子在水泥颗粒上的吸附引起的粘附效应。将海藻酸钠和柠檬酸钠添加到CPC中，CPC由磷酸肌醇的螯合键合能力设定，并且主要由α-磷酸三钙（α-TCP）相组成（>90%）。含海藻酸钠和柠檬酸钠的CPC的抗压强度为3.4 ± 0.3MPa，显著高于不含添加剂的CPC。此外，该骨水泥表现出良好的骨传导性和生物可吸收性，并在猪胫骨模型中植入4周后保持α-TCP相。这些结果表明，该骨水泥是生物可吸收糊状人工骨的潜在候选材料。© 2017威利期刊公司. J Biomed Mater Res Part B：Appl Biomater，106 B：2361-2370，2018。
Moldable and injectable calcium‐phosphate cements (CPCs) are material candidates for bone replacement applications. In the present study, we examined the effectiveness of sodium alginate and sodium citrate additives to the liquid phase of CPC, in improving its handling property as well as mechanical strength. The use of these additives enhanced the handling property significantly, in terms of consistency as compared to CPC without additives due to the liquefying effect caused by the adsorption of citrate ions on the cement particles. Sodium alginate and sodium citrate were added to CPC, which was set by the chelate‐bonding capability of inositol phosphate, and was composed of mainly α‐tricalcium phosphate (α‐TCP) phase (>90%). The compressive strength of the CPC containing sodium alginate and sodium citrate was 3.4 ± 0.3 MPa, which was significantly higher than cement without additives. Furthermore, this cement exhibited favorable osteoconductivity and bioresorbability, and remained the α‐TCP phase after 4‐week implantation in a pig tibiae model. These results suggested that the cement is a potential candidate as a bioresorbable paste‐like artificial bone. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2361–2370, 2018.