Mesenchymal stem cells in cartilage regeneration.
Mesenchymal stem cells in cartilage regeneration.
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DOI：
10.2174/1574888x09666140709111444
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发表时间：
2014-10
影响因子：
2.7
通讯作者：
V. Savkovic;Hanluo Li;J. Seon;M. Hacker;S. Franz;J. Simon
中科院分区：
文献类型：
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作者：
V. Savkovic;Hanluo Li;J. Seon;M. Hacker;S. Franz;J. Simon
关节软骨以其优异的生物力学性能和简单的结构提供了终身的承重和机械润滑。然而，关节软骨明显容易受到多因素的损伤，自身修复能力不足，孤立于无神经或血管的关节囊内。骨关节炎是一种进行性影响世界上相当大比例人口的退行性关节软骨缺陷性疾病，修复透明软骨是修复关节软骨损伤和重建长期正常功能的临床挑战。间充质干细胞(MSC)是一种高增殖、多能的体细胞，能够分化为中胚层来源的细胞，包括软骨细胞和成骨细胞。在基础研究和临床前试验的不断努力下，MSCs在软骨再生方面取得了可喜的成果。本文从组织工程、三维生物材料和生长因子等方面综述了基于MSC的透明软骨修复的原理和技术。通过比较传统的治疗方法和目前的研究进展，我们描述了在翻译和应用基于MSC的软骨形成治疗骨性关节炎方面的优势和挑战。
Articular cartilage provides life-long weight-bearing and mechanical lubrication with extraordinary biomechanical performance and simple structure. However, articular cartilage is apparently vulnerable to multifactorial damage and insufficient to self-repair, isolated in articular capsule without nerves or blood vessels. Osteoarthritis (OA) is known as a degenerative articular cartilage deficiency progressively affecting large proportion of the world population, and restoration of hyaline cartilage is clinical challenge to repair articular cartilage lesion and recreate normal functionality over long period. Mesenchymal stem cells (MSC) are highly proliferative and multipotent somatic cells that are able to differentiate mesoderm-derived cells including chondrocytes and osteoblasts. Continuous endeavors in basic research and preclinical trial have achieved promising outcomes in cartilage regeneration using MSCs. This review focuses on rationale and technologies of MSC-based hyaline cartilage repair involving tissue engineering, 3D biomaterials and growth factors. By comparing conventional treatment and current research progress, we describe insights of advantage and challenge in translation and application of MSC-based chondrogenesis for OA treatment.