Development and Validation of a Five-immune Gene Pair Signature in Endometrial Carcinoma
Development and Validation of a Five-immune Gene Pair Signature in Endometrial Carcinoma
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DOI：
10.2174/1386207323999200729113641
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发表时间：
2021-01-01
影响因子：
1.8
通讯作者：
Zeng, Dingyuan
中科院分区：
文献类型：
--
作者：
Li, Nan;Yu, Kai;Zeng, Dingyuan
背景：子宫内膜癌是世界范围内常见的妇科恶性肿瘤。免疫功能与EC的发生和预后密切相关。同时，免疫相关基因在多种肿瘤中作为预后标记物的潜力很大。目的：我们尝试开发免疫相关基因标记物，以提高对癌预后的预测。方法：从癌症基因组图谱(TCGA)下载542例EC基因表达数据和临床随访信息。样本被随机分为两组，一组为训练集(N=271)，另一组为验证组。(n=271)。在训练集中，根据271个免疫基因的相对表达水平建立基因对，筛选预后相关基因对。利用套索进行特征选择，最终筛选出稳健的生物标志物。结果：共获得10030个免疫基因对(IRGP)，单因素生存分析筛选出1809个与预后相关的IRGP(p
Background: Endometrial cancer (EC) is a common gynecological malignancy worldwide. Immunity is closely related to the occurrence and prognosis of EC. At the same time, immune-related genes have great potential as prognostic markers in many types of cancer.Objective: Therefore, we attempt to develop immune-related gene markers to enhance prognosis prediction of EC.Methods: 542 samples of EC gene expression data and clinical follow-up information were downloaded from The Cancer Genome Atlas (TCGA). The samples were randomly divided into two groups, one group as a training set (N=271), and one set as a validation set. (N=271). In the training set, the gene pairs were established based on the relative expression levels of 271 immune genes, and the prognosis-related gene pairs were screened. The lasso was used to select the features, and finally, the robust biomarkers were screened. Finally, the prognostic model of the immune gene pair was established and verified by the validation data set.Results: 10030 immune gene pair (IRGPs) were obtained, and univariate survival analysis was used to identify 1809 prognostic-related IRGPs (p