Tumor Volume in Radical Prostatectomy Specimens Assessed by Digital Image Analysis Software Correlates With Other Prognostic Factors
Tumor Volume in Radical Prostatectomy Specimens Assessed by Digital Image Analysis Software Correlates With Other Prognostic Factors
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DOI：
10.1016/j.juro.2010.01.017
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发表时间：
2010-05-01
影响因子：
6.6
通讯作者：
Mills, John
中科院分区：
文献类型：
--
作者：
Sherwin, Justin C.;Mirmilstein, George;Mills, John
目的：数字图像分析软件审查组织病理学标本是推进泌尿系病理学的客观性和可重复性。主观病理学家评估的前列腺肿瘤体积计算与根治性前列腺切除术中的已知预后因素相关。我们确定是否图像分析软件计算的前列腺肿瘤体积与这些预后因素，特别是积极的手术margins.Materials和方法：前列腺肿瘤体积计算使用数字图像分析软件在851个连续的根治性前列腺切除术标本，结果与临床病理资料进行Logistic回归。结果：前列腺肿瘤体积中位数为2.2 cc（IQR 0.9-3.8）。中位外周和移行区肿瘤体积分别为1.9和0.6 cc。移行区肿瘤236例（27.8%），手术切缘阳性244例（28.7%）。具有广泛阳性手术切缘的肿瘤比仅具有局灶性阳性手术切缘的肿瘤具有更大的图像分析软件评估的前列腺肿瘤体积（p = 0.029）和外周区体积（p = 0.007）。在单因素分析中，手术切缘阳性的肿瘤比手术切缘阴性的肿瘤更大，有精囊侵犯，前列腺外侵犯，神经周围侵犯和术前前列腺特异性抗原更高（每个P
Purpose: Digital image analysis software to review histopathology specimens is advancing uropathology by objectivity and reproducibility. Subjective pathologist assessed prostate tumor volume calculations correlate with known prognostic factors at radical prostatectomy. We ascertained whether image analysis software calculations of prostate tumor volume correlate with such prognostic factors, particularly positive surgical margins.Materials and Methods: Prostate tumor volume was calculated using digital image analysis software in 851 sequential radical prostatectomy specimens.Results were correlated with clinicopathological data by logistic regression. Results: Median prostate tumor volume was 2.2 cc (IQR 0.9-3.8). Median peripheral and transition zone tumor volume was 1.9 and 0.6 cc, respectively. Transition zone tumors were noted in 236 specimens (27.8%) and positive surgical margins occurred in 244 (28.7%). Tumors with extensive positive surgical margins had larger image analysis software assessed prostate tumor volume (p = 0.029) and peripheral zone volume (p = 0.007) than those with only focal positive surgical margins. On univariate analysis positive surgical margin tumors were larger and had seminal vesicle invasion, extraprostatic extension, perineural invasion and higher preoperative prostate specific antigen than those without positive surgical margins (each p