Surviving apoptosis: life-death signaling in single cells.
Surviving apoptosis: life-death signaling in single cells.
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DOI：
10.1016/j.tcb.2015.03.003
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发表时间：
2015-08
影响因子：
19
通讯作者：
Sorger PK
中科院分区：
文献类型：
--
作者：
Flusberg DA;Sorger PK
组织发育和体内平衡是由相反的促生存和促死亡信号调节的。肿瘤坏死因子（TNF）配体家族的一个有趣特征是它们通过相同的配体-受体复合物同时激活单个细胞内的相反信号。促死亡事件（如半胱天冬酶活化）和促存活事件（如NF-κB活化）的幅度不仅在不同细胞类型之间不同，而且在同一类型的单个细胞之间也因内在和外在噪声而不同。参与这些促生存/促死亡途径的分子，以及由其活性导致的不同表型，最近已被审查。在这里，我们专注于这些相反的信号的强度对塑造细胞命运决定的细胞与细胞之间的变化的影响。
Tissue development and homeostasis are regulated by opposing pro-survival and pro-death signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that they simultaneously activate opposing signals within a single cell via the same ligand-receptor complex. The magnitude of pro-death events such as caspase activation and pro-survival events such as NF-κB activation vary not only from one cell type to the next but also among individual cells of the same type due to intrinsic and extrinsic noise. The molecules involved in these pro-survival/pro-death pathways, and the different phenotypes that result from their activities, have been recently reviewed. Here we focus on the impact of cell-to-cell variability in the strength of these opposing signals on shaping cell fate decisions.