Disease burden of varicella versus other vaccine-preventable diseases before introduction of vaccination into the national immunisation programme in the Netherlands
Disease burden of varicella versus other vaccine-preventable diseases before introduction of vaccination into the national immunisation programme in the Netherlands
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在将疫苗纳入荷兰国家免疫计划之前，水痘与其他疫苗可预防疾病的疾病负担
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
H. D. de Melker
中科院分区：
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作者：
A. van Lier;B. de Gier;S. McDonald;M. Mangen;M. van Wijhe;E. Sanders;M. Kretzschmar;H. van Vliet;H. D. de Melker
估算疾病负担（BoD）是将新疫苗引入国家免疫规划（NIP）决策过程中必不可少的第一步。水痘是一种常见的疫苗可预防疾病，荷兰的BoD未知。目的评估全国水痘的BOD，并将其与其他疫苗可预防疾病的BOD进行比较，然后将其引入NIP。方法在这项健康评估报告研究中，使用欧洲传染病负担（BCoDE）项目的方法，以残疾调整生命年（DDEs）表示BoD。由于BCoDE工具包中没有水痘（包括带状疱疹）的参数/疾病模型，因此发病率、疾病进展模型和参数来自血清阳性率、医疗保健登记和已发表的数据。对于大多数其他疾病，BoD是用现有的BCoDE参数估计的，如果需要的话，可以根据荷兰的情况进行调整。结果2017年，荷兰水痘的估计BOD为1，800（95%不确定区间（UI）：1，800 - 1，900）Dods。带状疱疹主要促成了这一BoD（1，600 Dods; 91%），这通常低于大多数当前NIP疾病在引入NIP前一年的BoD。然而，水痘的BoD高于轮状病毒胃肠炎（1，100; 95%UI：440- 2，200 Days）和脑膜炎球菌B病（620; 95%UI：490-770 Days），这是另外两种潜在的NIP候选者。结论当考虑在NIP中引入新疫苗时，通常单独估计BoD。目前的方法评估了与其他疫苗可预防疾病的BOD相关的BOD，这可能有助于国家免疫咨询委员会和政策制定者确定疫苗接种的优先事项。
Introduction Estimating burden of disease (BoD) is an essential first step in the decision-making process on introducing new vaccines into national immunisation programmes (NIPs). For varicella, a common vaccine-preventable disease, BoD in the Netherlands was unknown. Aim To assess national varicella BoD and compare it to BoD of other vaccine-preventable diseases before their introduction in the NIP. Methods In this health estimates reporting study, BoD was expressed in disability-adjusted life years (DALYs) using methodology from the Burden of Communicable Diseases in Europe (BCoDE)-project. As no parameters/disease model for varicella (including herpes zoster) were available in the BCoDE toolkit, incidence, disease progression model and parameters were derived from seroprevalence, healthcare registries and published data. For most other diseases, BoD was estimated with existing BCoDE-parameters, adapted to the Netherlands if needed. Results In 2017, the estimated BoD of varicella in the Netherlands was 1,800 (95% uncertainty interval (UI): 1,800–1,900) DALYs. Herpes zoster mainly contributed to this BoD (1,600 DALYs; 91%), which was generally lower than the BoD of most current NIP diseases in the year before their introduction into the NIP. However, BoD for varicella was higher than for rotavirus gastroenteritis (1,100; 95%UI: 440–2,200 DALYs) and meningococcal B disease (620; 95%UI: 490–770 DALYs), two other potential NIP candidates. Conclusions When considering the introduction of a new vaccine in the NIP, BoD is usually estimated in isolation. The current approach assesses BoD in relation to other vaccine-preventable diseases’ BoD, which may help national advisory committees on immunisation and policymakers to set vaccination priorities.