The Whole (Cell) Is Less Than the Sum of Its Parts.
The Whole (Cell) Is Less Than the Sum of Its Parts.
复制标题
整个（单元格）小于其部分的总和。
DOI：
10.1016/j.cell.2016.08.011
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发表时间：
2016-08-25
期刊：
影响因子：
64.5
通讯作者：
Rutter J
中科院分区：
文献类型：
--
作者：
Van Vranken JG;Rutter J
尽管代谢物分析技术取得了进展，但细胞代谢全貌一直受到亚细胞区室化的限制，这种区室化将不同的营养物质库分隔在膜结合的细胞器中。现在，陈等人描述了克服这一障碍的方法，并提供了线粒体代谢组的新的定量图谱。
Despite advances in metabolite profiling, a full picture of the metabolic landscape of the cell has been limited by sub-cellular compartmentalization, which segregates distinct nutrient pools into membrane-bound organelles. Now, Chen et al. describe methods for overcoming this hurdle and provide a new quantitative picture of the mitochondrial metabolome.