Room Temperature Direct Alkynylation of 1,3,4-Oxadiazoles with Alkynyl Bromides under Copper Catalysis
Room Temperature Direct Alkynylation of 1,3,4-Oxadiazoles with Alkynyl Bromides under Copper Catalysis
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DOI：
10.1021/jo9025622
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发表时间：
2010-03-05
影响因子：
3.6
通讯作者：
Miura, Masahiro
中科院分区：
文献类型：
--
作者：
Kawano, Tsuyoshi;Matsuyama, Naoto;Miura, Masahiro
1,3,4-恶二唑与炔基溴的直接炔基化反应在铜催化剂存在下在室温下有效进行，以良好的产率产生相应的杂芳基-炔基键。这种直接偶联提供了对恶二唑核心π共轭系统的快速、收敛的访问。
The direct alkynylation reaction of 1,3,4-oxadiazoles with alkynyl bromides efficiently proceeds In the presence of a copper catalyst at room temperature to create the corresponding heteroaryl-alkynyl linkage in good yields. This direct coupling provides a rapid and convergent access to oxadiazole core pi-conjugated systems.