Dietary Lead Exposure and Associated Health Risks in Guangzhou, China
Dietary Lead Exposure and Associated Health Risks in Guangzhou, China
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DOI：
10.3390/ijerph16081417
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发表时间：
2019-04
影响因子：
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通讯作者：
Man Wang;B. Liang;Weiwei Zhang;Kuncai Chen;Yuhua Zhang;Hongwei Zhou;Yanfang Cheng;Hua-Zhang Liu;X. Zhong;Yingyue Li;Yufei Liu
中科院分区：
文献类型：
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作者：
Man Wang;B. Liang;Weiwei Zhang;Kuncai Chen;Yuhua Zhang;Hongwei Zhou;Yanfang Cheng;Hua-Zhang Liu;X. Zhong;Yingyue Li;Yufei Liu
铅接触会对人体健康产生广泛的不利影响。一般人群的主要接触途径是通过饮食。在这项研究中，我们估计了中国广州居民的膳食铅摄入量和相关的健康风险。铅浓度数据来自食品安全风险监测系统，该系统包括2014-2017年收集的27个食品类别的6339个样本。食品消费数据来自2011年对广州998户2960名居民的膳食调查。按年龄组（3-6岁、7-17岁、18-59岁和≥60岁）估算膳食铅摄入量，并采用接触边际（MOE）法评估相关健康风险。3 ~ 6岁学龄前儿童日铅摄入量均值和95百分位数（P95）分别为0.7466和2.4525 μg/kg体重；7 ~ 17岁学龄儿童分别为0.4739和1.5522 μg/kg体重/天；18 ~ 59岁成人为0.3759和1.1832 μg/kg bw/d；≥60岁成人为0.4031和1.3589 μg/kg bw/d。学龄前儿童在平均暴露水平下的MOE值小于1，所有年龄组在P95暴露水平下的MOE值小于1。大米及其制品、叶类蔬菜和小麦粉及其制品是铅暴露的主要食物来源。我们的研究结果表明，广州居民饮食铅暴露的健康风险总体较低，但幼儿和某些食物的消费者可能面临更高的风险。需要继续努力减少广州居民的饮食铅暴露。
Lead exposure is associated with a wide range of adverse effects on human health. The principal exposure route in the general population is through the diet. In this study, we estimate the dietary lead intake and associated health risks among the residents of Guangzhou, China. Data on lead concentrations were derived from the food safety risk monitoring system, which included 6339 samples from 27 food categories collected in 2014–2017. Food consumption data were taken from a 2011 dietary survey of 2960 Guangzhou residents from 998 households. Dietary lead intake was estimated by age group (3–6, 7–17, 18–59, and ≥60 years), and relevant health risks were assessed using the margin of exposure (MOE) method. The mean and 95th percentiles (P95) of dietary lead intake were respectively 0.7466 and 2.4525 μg/kg body weight per day for preschool children aged 3–6 years; 0.4739 and 1.5522 μg/kg bw/day for school children aged 7–17 years; 0.3759 and 1.1832 μg/kg bw/day for adults aged 18–59 years; and 0.4031 and 1.3589 μg/kg bw/day for adults aged ≥60 years. The MOE value was less than 1 for preschool children at the mean exposure level and for all age groups at the P95 exposure level. Rice and its products, leafy vegetables, and wheat flour and its products were found to be the primary food sources of lead exposure. Our findings suggest that the health risk from dietary lead exposure is low for Guangzhou residents overall, but that young children and consumers of certain foods may be at increased risk. Continued efforts are needed to reduce the dietary lead exposure in Guangzhou.