[Estrogen receptor status and expression of carbohydrate antigens in breast cancer].
[Estrogen receptor status and expression of carbohydrate antigens in breast cancer].
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乳腺癌中雌激素受体状态和碳水化合物抗原的表达。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
M. Kawahara
中科院分区：
文献类型：
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作者：
M. Sowa;Y. Chung;Y. Kato;M. Nishimura;T. Kubo;H. Maekawa;Y. Fujimoto;K. Umeyama;M. Kawahara
本文对76例原发性乳腺癌进行了临床病理学观察和单克隆抗体免疫组织化学研究。雌激素受体（ER）阳性40例，阴性36例，阳性率为52.6%。绝经后组ER阳性率高于绝经前组，但两组ER阳性率无显著性差异。与ER阳性病例相比，ER阴性病例的肿瘤较大（大于t3），淋巴结转移程度较高。SPan-1、CA 19-9和SLEX的糖抗原检出率分别为34.2%、39.5%和68.4%。这些抗原在大肿块和高级别转移的病例中比在小肿块和无转移或低级别转移的病例中更常检测到，如果不是显著的。SPan-1阳性率在分级为t1或t2的ER阴性病例中显著高于在相同肿瘤大小类别下ER阳性病例。ER阴性组和ER阳性组在CA 19-9阳性率（t2类）和SLEX阳性率（t3类）方面也存在显著差异。当我们的病例按淋巴结转移程度分类时，也得到了类似的数据。因此，目前的观察表明，糖抗原在原发性乳腺癌和疾病进展的表达可能与ER状态。
Seventy-six cases of primary cancer of the breast were studied by clinicopathological examination and immunohistological examination using monoclonal antibodies. They were composed of 40 cases positive for estrogen receptor (ER) and 36 cases negative for ER, the ER-positive rate being 52.6%. ER was detected more frequently in the postmenopausal group than in the premenopausal group, though the ER-positive rate was not significantly different between the two groups. The disease was advanced with a large tumor (greater than t3) and high-grade lymph node metastasis in ER-negative cases compared with ER-positive cases. The carbohydrate antigens specific to SPan-1, CA 19-9 and SLEX were found in 34.2%, 39.5% and 68.4% of the cases studied, respectively. These antigens were detected more often, if not significantly, in cases with a large mass and high-grade metastasis than in those with a small mass and without metastasis or with low-grade metastasis. The SPan-1-positive rate was significantly higher in ER-negative cases graded t1 or t2 than in ER-positive cases falling under the same category of tumor size. Significant differences were also noticed between the ER-negative and ER-positive groups with respect to CA 19-9-positive rate (t2 category) and SLEX-positive rate (t3 category). Similar data were obtained when our cases were classified by the degree of lymph node metastasis. In consequence, the present observations suggested that the expression of carbohydrate antigens in primary breast cancer and disease progress might be correlated with ER status.