Stress-induced facilitation of the cortisol response in 17α-hydroxylase deficient XX mas-1/mas-1 carp (Cyprinus carpio)
Stress-induced facilitation of the cortisol response in 17α-hydroxylase deficient XX mas-1/mas-1 carp (Cyprinus carpio)
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DOI：
10.1016/j.ygcen.2006.11.008
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发表时间：
2007-02-01
影响因子：
2.7
通讯作者：
Komen, J.
中科院分区：
文献类型：
--
作者：
Ruane, N. M.;Goos, H. J. Th.;Komen, J.
Facilitation of the stress response results from a reduction of the inhibitory effects of circulating corticosteroids, allowing an animal to respond to a novel stressor. In this study, the existence of a facilitated cortisol stress response in normal (STD) and 17 alpha-hydroxylase deficient XX mas(-1)/mas(-1) (E5) carp was investigated. E5 carp had previously been characterized as having a low cortisol response to stress. Fish were subjected to either cortisol feeding or daily-acute stress, from 45 until 140 days post-hatch (dph) and were then subjected to a novel net-confinement stressor at 141 dph. Growth of E5 fish was reduced in both the daily-acute stress and cortisol-fed groups, but STD fish were only affected by daily-acute stress. Cortisol feeding had no effect on the stress response of STD fish but daily-acute stress significantly inhibited the response to a subsequent novel stressor. In contrast, daily-acute stress facilitated the cortisol stress response of E5 fish to a novel stressor, while cortisol feeding inhibited the cortisol response. Facilitation was accompanied by significant enlargement of the head-kidney tissue (which contains the steroidogenic interrenal tissue) in E5 fish. To our knowledge this is the first report of stress-induced facilitation in a lower vertebrate. (c) 2006 Elsevier Inc. All rights reserved.
