Increasing the selectivity of drug discrimination procedures
Increasing the selectivity of drug discrimination procedures
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DOI：
10.1016/s0091-3057(99)00089-1
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发表时间：
1999-10-01
影响因子：
3.6
通讯作者：
Pechersky, K
中科院分区：
文献类型：
--
作者：
Appel, JB;West, WB;Pechersky, K
为了提高药物辨别的选择性，训练大鼠将LSD(0.08 mg/kg)与一组由可卡因(10 mg/kg)、戊巴比妥(5 mg/kg)和生理盐水组成的“其他”化合物区分开来。在配备了可伸缩杠杆的小室中，这种LSD-其他辨别能力的获得很快(31天)，与一组接受过区分LSD和生理盐水的训练的动物(26天)没有显著差异。在替代(泛化)测试中，迷幻剂如LSD、DMT和DOM在两组中都以剂量依赖的方式模仿LSD。在LSD-OTHER组，设计药物(+/-)MDMA替代LSD(ED50=1.38)，但在LSD-ND组，(+/-)MDMA不替代训练药物；(+)MDMA和PCP在两组中都不能模拟LSD。最重要的是，利尿胺、奎帕津和育亨宾，这些被描述为“假阳性”的药物，在经过训练以区分LSD和生理盐水的动物中替代了LSD(ED(50)S分别=0.012，1.662，2.344)，但在经过训练以区分LSD和其他药物的动物中不存在。因此，LSD-Other训练程序可以被描述为比标准的药物-ND程序更有选择性。(C)1999年爱思唯尔科学公司。
In an attempt to increase the selectivity of drug discrimination, rats were trained to discriminate LSD (0.08 mg/kg) from a group of "other" compounds consisting of cocaine (10 mg/kg), pentobarbital (5 mg/kg), and saline. Acquisition of this LSD-other discrimination was rapid (31 days) in chambers equipped with retractable levers and did not differ significantly from that of a group of animals trained to discriminate LSD from saline (26 days). In substitution (generalization) tests, hallucinogens such as LSD, DMT, and DOM mimicked LSD in a dose-dependent manner in both groups. The designer drug (+/-) MDMA substituted for LSD in the LSD-other group (ED50 = 1.38) but did not substitute for the training drug in the LSD-ND group; neither (+) MDMA nor PCP mimicked LSD in either group. Most importantly, lisuride, quipazine, and yohimbine, drugs that have been described as "false positives," substituted for LSD in animals trained to discriminate LSD from saline (ED(50)s = 0.012, 1.662, 2.344, respectively), but not in animals trained to discriminate LSD from other drugs. Thus, the LSD-other training procedure can be described as more selective than the standard drug-ND procedure. (C) 1999 Elsevier Science Inc.