Effect of soybean on breast cancer according to receptor status: A case-control study in Japan
Effect of soybean on breast cancer according to receptor status: A case-control study in Japan
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DOI：
10.1002/ijc.23644
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发表时间：
2008-10-01
影响因子：
6.4
通讯作者：
Tajima, Kazuo
中科院分区：
文献类型：
--
作者：
Suzuki, Takeshi;Matsuo, Keitaro;Tajima, Kazuo
在亚洲国家，大量食用大豆食品与低乳腺癌发病率之间的可能联系已经得到了广泛的调查，但流行病学研究的结果并不一致。由受体状态、雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)定义的乳腺癌可能有不同的病因。在这里，我们进行了一项病例对照研究，根据受体状态来阐明大豆制品的摄入与乳腺癌风险之间的关系。共有678例乳腺癌病例和3390名年龄和绝经状况匹配的非癌症对照纳入研究。使用调整了潜在混杂因素的条件Logistic模型估计了具有95%可信区间(CI)的优势比(OR)。根据受体状态进行分析，我们观察到ER阳性(ER+)(TOP可育OR=0.74；95%CI，0.58-0.94；趋势P=0.01)和HER2阴性(HER2-)肿瘤的风险显著降低(TOP可育OR=0.78；95%CI，0.61-0.99；趋势P=0.04)。此外，当3种受体联合检测时，仅在R+/PR+/HER2-肿瘤患者中观察到风险降低(TOP可育OR=0.7；95%CI，0.54-0.97；趋势P=0.03)。这些发现表明，大豆对乳腺癌风险的保护作用因受体状态而异。(C)2008年Wiley-Liss，Inc.
The possible association of high soy food consumption with low incidence of breast cancer in Asian countries has been widely investigated, but findings from epidemiologic studies have been inconsistent. Breast cancers defined by receptor status, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) may have distinct etiologic factors. Here, we conducted a case-control study to clarify associations between intake of soybean products and breast cancer risk according to receptor status. A total of 678 breast cancer cases and 3,390 age- and menopausal status-matched noncancer controls were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using conditional logistic models adjusted for potential confounders. On analysis according to receptor status, we observed a significantly reduced risk of ER-positive (ER+) (top fertile OR = 0.74; 95% CI, 0.58-0.94; trend p = 0.01) and HER2-negative (HER2-) tumors (top fertile OR = 0.78; 95% CI, 0.61-0.99; trend p = 0.04). Further, when the 3 receptors were jointly examined, a reduced risk was observed only in patients with R+/PR+/HER2- tumor (top fertile OR = 0.7; 95% CI, 0.54-0.97; trend p = 0.03). These findings indicate that the protective effect of soy against breast cancer risk differs by receptor status. (C) 2008 Wiley-Liss, Inc.