PREMATURE CENTROMERE DIVISION DOMINANTLY INHERITED IN A SUBFERTILE FAMILY
PREMATURE CENTROMERE DIVISION DOMINANTLY INHERITED IN A SUBFERTILE FAMILY
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DOI：
10.1159/000132299
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
GLOVER, G
中科院分区：
文献类型：
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作者：
GABARRON, J;JIMENEZ, A;GLOVER, G
有丝分裂的频率增加，显示过早的着丝粒分裂（PCD）在每条染色体被发现在淋巴细胞培养从四个亚不育家族的成员。在秋水仙碱存在和不存在的情况下观察这些细胞。先证者培养的成纤维细胞仅显示正常的二倍体中期。PCD细胞似乎具有较短的细胞周期。在这个家庭中，这种异常以一种与常染色体显性遗传相容的方式传播。
An increased frequency of mitoses showing premature centromere division (PCD) in every chromosome was found in lymphocyte cultures from four members of a subfertile family. These cells were observed in both the presence and absence of colchicine. Cultured fibroblasts from the proband showed only normal diploid metaphases. PCD cells seemed to have a shorter cell cycle. The anomaly was transmitted in a way compatible with autosomal dominant inheritance in this family.