Efficacy of a new macrolide (azithromycin). For acute otitis media in the chinchilla model.
Efficacy of a new macrolide (azithromycin). For acute otitis media in the chinchilla model.
复制标题
新大环内酯类药物（阿奇霉素）的功效。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
D. Kardatzke
中科院分区：
文献类型：
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作者：
K. Chan;J. Swarts;W. Doyle;K. Tanpowpong;D. Kardatzke
使用灰鼠动物模型评价了研究性大环内酯类药物阿奇霉素治疗由产β-内酰胺酶流感嗜血杆菌菌株感染引起的急性中耳炎的疗效。结果表明，阿奇霉素高剂量组（30 mg/kg/d）的积液灭菌率和消退率显著高于其他治疗组。证明了这种试验用抗菌剂的独特药代动力学特性。阿奇霉素治疗上呼吸道感染，包括中耳炎的临床试验是必要的。
The efficacy of an investigational macrolide, azithromycin, in the treatment of acute otitis media consequent to an infection by a strain of beta-lactamase-producing Haemophilus influenzae, was evaluated using the chinchilla animal model. The results indicate that the azithromycin high-dosage (30 mg/kg/d) group has a significantly higher rate for effusion sterilization and resolution as compared with the other treatment groups. Unique pharmacokinetic properties of this investigational antimicrobial were demonstrated. Clinical trials using azithromycin for the treatment of upper respiratory tract infections, including otitis media, are warranted.
DOI：
10.1001/archotol.1983.00800220039010
发表时间：
1983
期刊：
Archives of otolaryngology (Chicago, Ill. : 1960)
影响因子：
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作者：
Reilly,JS;Doyle,WJ;Cantekin,EI;Supance,JS;Kim,HK;Rohn,DD;Bluestone,CD
通讯作者：
Bluestone,CD