Sleep disorders and daytime sleepiness in children with attention-deficit/hyperactive disorder
Sleep disorders and daytime sleepiness in children with attention-deficit/hyperactive disorder
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DOI：
10.1093/sleep/27.2.261
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发表时间：
2004-03-15
期刊：
影响因子：
5.6
通讯作者：
Pillar, G
中科院分区：
文献类型：
--
作者：
Golan, N;Shahar, E;Pillar, G
研究目的：患有注意力缺陷多动障碍（ADHD）的儿童尽管多动，但仍然可以从兴奋剂药物治疗中获益。我们假设患有ADHD的儿童在白天实际上是困倦的，并且我们试图客观地测试它。设计：单盲比较研究设置：大学医学中心参与者：34名先前诊断为ADHD的儿童（平均年龄SD，12.4 ± 4.6岁）和32例匹配对照（平均年龄，12.0 +/- 3.6岁）。所有参与者都接受了一整夜的多导睡眠图研究，然后进行了多次睡眠潜伏期测试（MPEST）。各组之间的睡眠潜伏期、总睡眠时间和睡眠效率相当，然而，ADHD儿童在白天比对照组明显更困倦（平均MPEG4评分为21.9 +/- 5.5分钟对27.9 +/- 2.0分钟，P <0.005）。在ADHD儿童中，17名（50%）有睡眠呼吸障碍的迹象，而对照组有7名（22%，P <0.05）。注意力缺陷多动障碍组中有5人（15%）在睡眠中有周期性肢体运动，而对照组中没有。没有睡眠呼吸障碍或周期性肢体运动的儿童在sleep.Conclusions夜间睡眠效率和总睡眠时间最低：我们的结论是，ADHD儿童表现出客观的白天嗜睡，这可以解释与兴奋剂药物治疗的有益效果。原发性睡眠障碍，特别是睡眠呼吸障碍和周期性肢体运动障碍，应该在ADHD儿童中寻找。
Study Objectives: Children with attention-deficit/hyperactive disorder (ADHD), in spite of being hyperactive, still benefit from treatment with stimulant medications. We hypothesized that children with ADHD are in fact sleepy during the day, and we sought to test it objectively.Design: Single blind comparative studySetting: University medical centerParticipants: Thirty-four children with a previous diagnosis of ADHD (mean age SD, 12.4 +/- 4.6 years) and 32 matched controls (mean age, 12.0 +/- 3.6 years).Interventions: N/A.Measurements: All participants underwent a full-night polysomnographic study followed by a multiple sleep latency test (MSLT).Results: Sleep latency, total sleep time, and sleep efficiency were comparable between the groups, yet children with ADHD were significantly sleepier during the day than those in the control group (mean MSLT score of 21.9 +/- 5.5 minutes versus 27.9 +/- 2.0 minutes, P < .005). Of the children with ADHD, 17 (50%) had signs of sleep-disordered breathing, compared with 7 of the control group (22%, P < .05). Five of the ADHD group had periodic limb movements during sleep (15%) versus none in the control group. Children without sleep-disordered breathing or periodic limb movements during sleep had the lowest nocturnal sleep efficiency and total sleep time.Conclusions: We conclude that children with ADHD demonstrate objective daytime somnolence, which may explain the beneficial effects of treatment with stimulant medications. Primary sleep disorders, especially sleep-disordered breathing and periodic limb movement disorder, should be looked for in children with ADHD.