Follicular shuttling of marginal zone B cells facilitates antigen transport
Follicular shuttling of marginal zone B cells facilitates antigen transport
复制标题
DOI：
10.1038/ni1542
复制
发表时间：
2008-01-01
影响因子：
30.5
通讯作者：
Cyster, Jason G.
中科院分区：
文献类型：
--
作者：
Cinamon, Guy;Zachariah, Marcus A.;Cyster, Jason G.
脾边缘区是血液流动的部位，居住在该区域的特化B细胞群与血源性抗原的捕获和滤泡递送有关。然而，这种抗原转运的机制仍然未知。在这里，我们发现边缘区B细胞并不局限于边缘区，而是不断穿梭于边缘区和卵泡区之间，使得许多细胞每隔几个小时访问一次卵泡。迁移到卵泡需要趋化因子受体CXCR 5，而返回到边缘区是由鞘氨醇1-磷酸受体S1 P（1）和S1 P（3）促进的。用SIP拮抗剂处理引起边缘区B细胞从边缘区移位。边缘区-滤泡穿梭的边缘区B细胞提供了一个有效的机制，全身抗原捕获和交付滤泡树突状细胞。
The splenic marginal zone is a site of blood flow, and the specialized B cell population that inhabits this compartment has been linked to the capture and follicular delivery of blood-borne antigens. However, the mechanism of this antigen transport has remained unknown. Here we show that marginal zone B cells were not confined to the marginal zone but continuously shuttled between the marginal zone and follicular areas, such that many of the cells visited a follicle every few hours. Migration to the follicle required the chemokine receptor CXCR5, whereas return to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P(1) and S1P(3). Treatment with an SIP, antagonist caused displacement of marginal zone B cells from the marginal zone. Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells.