Free dopamine in dog plasma: lack of relationship with sympathoadrenal activity.
Free dopamine in dog plasma: lack of relationship with sympathoadrenal activity.
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狗血浆中的游离多巴胺：与交感肾上腺活动缺乏关系。
DOI：
10.1152/jappl.1985.58.3.763
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发表时间：
1985
影响因子：
3.3
通讯作者：
R. Flandrois
中科院分区：
文献类型：
--
作者：
J. Pequignot;R. Favier;D. Desplanches;L. Peyrin;R. Flandrois
为了研究多巴胺（DA）释放到血流中与交感肾上腺活性之间的关系，在四只狗中记录了血浆中游离DA、去甲肾上腺素（NE）和肾上腺素（E）的水平，这些狗接受了三种试验：两种工作水平[55和75%最大O2摄取量; 15 min]的跑台运动、常压缺氧（12%O2; 1 h）、运动和缺氧联合。常氧运动导致动脉血氧分压（PaO 2）轻微非显著性降低，NE升高[次极量工作与休息期间的中位数和范围：1086（457- 1，637）vs. 360（221-646）pg/ml; P <0.01]和E [277（151-461）vs. 166（95-257）pg/ml; P <0.05]，但未能改变DA水平。缺氧引起PaO 2大幅下降[缺氧vs.常氧：42.8（40.3-50.0）vs. 97.6（83.2-117.6）Torr; P小于0.01]，DA增加[230（105-352）vs. 150（85-229）pg/ml; P <0.01]和NE [383（219- 1，165）vs. 358（210-784）pg/ml; P <0.05]，但未能改变E水平。运动和缺氧联合作用进一步增加NE水平，但不改变DA对缺氧的反应。这些数据表明，血浆中的游离DA可能独立于交感肾上腺活性而变化。
To investigate the relationship between dopamine (DA) released into the bloodstream and sympathoadrenal activity, levels of free DA, norepinephrine (NE), and epinephrine (E) in plasma were recorded in four dogs subjected to three tests: treadmill exercise at two work levels [55 and 75% maximal O2 uptake; 15 min], normobaric hypoxia (12% O2; 1 h), combined exercise and hypoxia. Normoxic exercise induced slight nonsignificant decreases in the arterial partial pressure of O2 (PaO2), increases in NE [median values and ranges during submaximal work vs. rest: 1086 (457-1,637) vs. 360 (221-646) pg/ml; P less than 0.01] and E [277 (151-461) vs. 166 (95-257) pg/ml; P less than 0.05], but it failed to alter the DA level. Hypoxia elicited large decreases in PaO2 [hypoxia vs. normoxia: 42.8 (40.3-50.0) vs. 97.6 (83.2-117.6) Torr; P less than 0.01], increases in DA [230 (105-352) vs. 150 (85-229) pg/ml; P less than 0.01] and NE [383 (219-1,165) vs. 358 (210-784) pg/ml; P less than 0.05], but it failed to alter the E level. Combined exercise and hypoxia further increased NE levels but did not alter the DA response to hypoxia alone. The data indicate that free DA in plasma may vary independently of the sympathoadrenal activity.