Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies
Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies
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DOI：
10.1093/jnci/djk181
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发表时间：
2007-05-16
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影响因子：
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通讯作者：
Smith-Warner, Stephanie A.
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文献类型：
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作者：
Lee, Jung Eun;Hunter, David J.;Smith-Warner, Stephanie A.
背景：在病例对照研究中，酒精摄入与肾细胞癌风险之间的关系并不一致。在一些前瞻性研究中，酒精摄入量与肾细胞癌的风险呈负相关，但每项研究都包括少量病例。方法我们对12项前瞻性研究进行了汇总分析，其中包括530469名女性和229575名男性，最长随访时间为7-20年。所有参与者在基线时都完成了一份有效的食物频率问卷。利用每项研究的原始数据，使用Cox比例风险模型计算研究特异性相对风险（rr），然后使用随机效应模型进行汇总。所有统计检验均为双侧检验。结果共检出1430例肾细胞癌，其中女性711例，男性719例。研究标准化的肾细胞癌发病率在不饮酒者中为23 / 100000人/年，在每天饮酒量为15克或更多的人群中为15 / 100000人/年。与不饮酒相比，饮酒（>= 15 g/天，相当于每天略多于一杯酒精饮料）与肾细胞癌风险降低相关（合并多变量RR = 0.72, 95%置信区间= 0.60 ~ 0.86；p趋势）
Background The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases.Methods We performed a pooled analysis of 12 prospective studies that included 530469 women and 229575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided.Results A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100000 person-years among nondrinkers and 15 per 100000 person-years among those who drank 15 g/day or more of alcohol. Compared with non-drinking, alcohol consumption (>= 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P-trend