Outbreaks of influenza A virus infection in neonatal intensive care units
Outbreaks of influenza A virus infection in neonatal intensive care units
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DOI：
10.1097/00006454-200203000-00007
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发表时间：
2002-03-01
影响因子：
3.6
通讯作者：
Vila, C
中科院分区：
文献类型：
--
作者：
Sagrera, X;Ginovart, G;Vila, C
背景医院内流感病毒感染的爆发在儿童期很少被描述，在新生儿期更是如此。我们报告30名新生儿入院2新生儿重症监护病房医院内甲型流感病毒感染，发生在1999年的2次爆发。评估感染的危险因素，并采取控制措施。用间接免疫荧光抗体筛选法检测病毒。任何鼻咽抽吸物甲型流感病毒阳性的婴儿被认为是感染。在95名接受筛查的婴儿中，有30名甲型流感病毒呈阳性（31.5%）。感染组的平均出生体重为1622 g，平均胎龄为31周。在未感染组中，平均出生体重为2594 g，平均胎龄为36.4周。低出生体重、短胎龄、双胎妊娠和机械通气是感染的危险因素。22例有临床症状，8例无症状。临床表现以呼吸道和消化道疾病为主。结果是有利的，在所有情况下。结论。流感病毒感染被认为是新生儿期医院感染的可能原因。控制措施和预防很重要。
Background. Outbreaks of nosocomial influenza virus infections have been described rarely during childhood and even less so in the neonatal period.Methods. We report 30 neonates admitted to 2 neonatal intensive care units with nosocomial influenza A virus infection, which occurred in 2 outbreaks during 1999. Risk factors for infection were evaluated, and control measures were adopted. Virus was detected by indirect immunofluorescence antibody screen. Any infant with nasopharyngeal aspirate positive for influenza A virus was considered infected.Results. Of 95 infants screened 30 were positive for influenza A virus (31.5%). Mean birth weight was 1622 g, and mean gestational age was 31 weeks in the infected group. In the noninfected group mean birth weight was 2594 g and mean gestational age was 36.4 weeks. Low birth weight, short gestational age, twin pregnancy and mechanical ventilation were identified as risk factors for infection. Clinical symptoms were seen in 22, and 8 were asymptomatic. Clinical features were predominantly respiratory and digestive. The outcome was favorable in all cases.Conclusions. Infection by influenza virus has to be considered as a possible cause of nosocomial infection in the neonatal period. Control measures and prevention are important.