Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats
Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats
复制标题
DOI：
10.1523/jneurosci.0124-06.2006
复制
发表时间：
2006-07-12
影响因子：
5.3
通讯作者：
Bear, Mark F.
中科院分区：
文献类型：
--
作者：
Iny, Karen;Heynen, Arnold J.;Bear, Mark F.
最近对啮齿动物视觉皮层的电生理研究表明，除了剥夺性眼压抑外，单眼剥夺（MD）还通过增强睁眼反应来转移眼优势。我们使用基于计算机的双选择辨别任务来评估这些发现在大鼠中的行为意义。正如预期的那样，从出生后第21天到成年（150天），长期的MD明显降低了通过被剥夺的眼睛的视力。然而，我们也发现，与正常饲养的对照组相比，未剥夺眼睛的敏锐度显着提高。有趣的是，当成年人打开被剥夺的眼睛时，被剥夺的眼睛的视力会逐渐恢复，但不完全恢复，在此之前，未被剥夺的眼睛的增强视力会丧失。通过再次闭合眼睛，这些变化被逆转了。这些发现表明，MD后视觉诱发反应的双向变化具有行为意义，并且在成年期也表现出显著的可塑性。
Recent electrophysiological studies of rodent visual cortex suggest that, in addition to deprived-eye depression, monocular deprivation (MD) also shifts ocular dominance by potentiation of open-eye responses. We used computer-based, two-choice discrimination tasks to assess the behavioral significance of these findings in rats. As expected, prolonged MD, from postnatal day 21 until adulthood (> 150 d) markedly decreased visual acuity through the deprived eye. However, we also found that the acuity through the nondeprived eye was significantly enhanced compared with normally reared controls. Interestingly, when the deprived eye was opened in adults, there was a gradual but incomplete recovery of acuity in the deprived eye preceded by a loss of the enhanced acuity in the nondeprived eye. These changes were reversed by again reclosing the eye. These findings suggest that the bidirectional changes in visually evoked responses after MD are behaviorally meaningful and that significant plasticity is exhibited well into adulthood.