Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis.
Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis.
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DOI：
10.1016/j.redox.2020.101614
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发表时间：
2020-10
期刊：
影响因子：
11.4
通讯作者：
Abe JI
中科院分区：
文献类型：
--
作者：
Dominic A;Banerjee P;Hamilton DJ;Le NT;Abe JI
衰老细胞的积累在包括动脉粥样硬化（AS）和心血管疾病（CVD）在内的年龄相关疾病的病理学中具有致病作用。然而，衰老的概念现在正在发生巨大的变化，衰老相关的重编程/干细胞性的新概念已经出现，这表明衰老不仅仅与“细胞周期停滞”或停止各种细胞功能有关。众所周知，扰动流（D-flow）加速了过早衰老，在AS的发展中起着重要作用。我们将讨论在这篇评论中，过早老化诱导的D-流是不可比的时间依赖性衰老，特别是与衰老相关的分泌表型（SASP）在衰老相关的重编程/干细胞，或增加细胞数量的可能参与的重点。我们还将提出我们的展望烟酰胺腺嘌呤二核苷酸（NAD）+缺陷诱导的线粒体活性氧（mtROS）通过激活DNA损伤反应（DDR）引起SASP。MtROS在核-线粒体、SASP和最终动脉粥样硬化形成之间的相互作用中起关键作用。尽管时间和各种应激因素诱导的衰老是一个经典的概念，但我们希望读者能够看到这个概念正在发生的哥白尼式的变化，以及认识到D流诱导的过早衰老与时间依赖性衰老之间的显著差异。
Accumulation of senescent cells has a causative role in the pathology of age-related disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the concept of senescence is now drastically changing, and the new concept of senescence-associated reprogramming/stemness has emerged, suggesting that senescence is not merely related to “cell cycle arrest” or halting various cellular functions. It is well known that disturbed flow (D-flow) accelerates pre-mature aging and plays a significant role in the development of AS. We will discuss in this review that pre-mature aging induced by D-flow is not comparable to time-dependent aging, particularly with a focus on the possible involvement of senescence-associated secretory phenotype (SASP) in senescence-associated reprogramming/stemness, or increasing cell numbers. We will also present our outlook of nicotinamide adenine dinucleotides (NAD)+ deficiency-induced mitochondrial reactive oxygen species (mtROS) in evoking SASP by activating DNA damage response (DDR). MtROS plays a key role in developing cross-talk between nuclear-mitochondria, SASP, and ultimately atherosclerosis formation. Although senescence induced by time and various stress factors is a classical concept, we wish that the readers will see the undergoing Copernican-like change in this concept, as well as to recognize the significant contrast between pre-mature aging induced by D-flow and time-dependent aging.
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
DOI：
10.1615/critreveukargeneexpr.v20.i1.60
发表时间：
2010-01-01
影响因子：
1.6
作者：
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通讯作者：
Zhang, Yanping
DOI：
10.1152/ajpheart.01047.2006
发表时间：
2007-03-01
影响因子：
4.8
作者：
Chien, Shu
通讯作者：
Chien, Shu
影响因子：
3.9
作者：
Collins, Caitlin;Tzima, Ellie
通讯作者：
Tzima, Ellie
影响因子：
64.5
作者：
Bandaria JN;Qin P;Berk V;Chu S;Yildiz A
通讯作者：
Yildiz A