Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects
Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects
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DOI：
10.1021/np050197e
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发表时间：
2006-05-26
影响因子：
5.1
通讯作者：
Hamann, Mark T.
中科院分区：
文献类型：
--
作者：
Peng, Jiangnan;Kasanah, Noer;Hamann, Mark T.
完成了从牙买加海绵海霉霉（Myrmekioderma styx）中分离的海洋二萜cyanthiwigin B(1)的微生物转化研究。两种放线菌培养物Streptomyces NRRL 5690和Streptomyces spheroides显著代谢了cyanthiwigin B为新的代谢物。Streptomyces NRRL 5690将cyanthiwigin B转化为三个新的化合物，即cyanthiwigin AE(2)、AF(3)和AG(4)，以及已知的cyanthiwigin R(5)。S. spheroides将cyanthiwigins B转化为cyanthiwigins S(6)、E(7)和AE(2)。cyanthiwigin B的所有微生物代谢衍生物（2-7）都显示出提高从冥河蓟中分离的主要抗菌倍半萜curcu酚的抗菌活性。
Microbial transformation studies of the marine diterpene cyanthiwigin B ( 1), isolated from the Jamaican sponge Myrmekioderma styx, were accomplished. Two actinomycete cultures, Streptomyces NRRL 5690 and Streptomyces spheroides, significantly metabolized cyanthiwigin B to new metabolites. Streptomyces NRRL 5690 transformed cyanthiwigin B to three new compounds, cyanthiwigins AE ( 2), AF ( 3), and AG ( 4), and the known cyanthiwigin R ( 5). S. spheroides transformed cyanthiwigin B to cyanthiwigins S ( 6), E ( 7), and AE ( 2). All microbial-metabolized derivatives ( 2-7) of cyanthiwigin B exhibited the ability to increase the antimicrobial activity of curcuphenol, the major antimicrobial sesquiterpene isolated from M. styx.