Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines
Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines
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DOI：
10.1016/s0264-410x(00)00161-4
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发表时间：
2000-10-15
期刊：
影响因子：
5.5
通讯作者：
Chelvarajan, RL
中科院分区：
文献类型：
--
作者：
Bondada, S;Wu, HJ;Chelvarajan, RL
T非依赖性抗原在不存在载体特异性T辅助细胞的情况下引发抗体应答，但需要来自辅助细胞（巨噬细胞和树突状细胞）或特异性细胞因子的信号。基于TI-1而不是TI-2抗原引起新生儿免疫应答的能力，它们进一步细分为TI-1和TI-2类别。大多数细菌多糖包括肺炎球菌多糖疫苗属于TI-2类。据推测，辅助细胞功能的缺陷在新生儿对这种TI-2抗原应答失败中起关键作用。对这些TI-2刺激的免疫应答在老年人中也减少，也是由于辅助细胞的定量缺乏。能够刺激辅助细胞功能的试剂可能提供一种替代策略，以提高多糖疫苗在新生儿和老年人中的免疫原性。(C)2000爱思唯尔科技有限公司版权所有。
T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide Vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd. All rights reserved.