PTSD is Associated With an Excess of Inflammatory Immune Activities
PTSD is Associated With an Excess of Inflammatory Immune Activities
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DOI：
10.1111/j.1744-6163.2009.00229.x
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发表时间：
2009-10-01
影响因子：
2.3
通讯作者：
Page, Gayle
中科院分区：
文献类型：
--
作者：
Gill, Jessica M.;Saligan, Leo;Page, Gayle
目的。创伤后应激障碍（PTSD）与炎症相关的医疗条件有关。本文回顾了创伤后应激障碍患者免疫功能的研究，以确定过度炎症是否与创伤后应激障碍有关。结论：目前的研究表明，慢性创伤后应激障碍患者免疫系统的过度炎症行为。高水平的炎症细胞因子也与创伤个体的PTSD易感性有关。也有证据表明，过度炎症的部分原因是皮质醇调节不足。实践意义。过度的炎症免疫活动可能会导致PTSD患者健康状况下降，而治疗PTSD症状可能会降低这些风险。
PURPOSE.Post-traumatic stress disorder (PTSD) is associated with inflammatory-related medical conditions. This review examines studies of immune function in individuals with PTSD to determine if excessive inflammation is associated with PTSD.CONCLUSIONS.Current studies suggest an excess of inflammatory actions of the immune system in individuals with chronic PTSD. High levels of inflammatory cytokines have also been linked to PTSD vulnerability in traumatized individuals. There is also evidence that excessive inflammation is in part due to insufficient regulation by cortisol.PRACTICE IMPLICATIONS.An excess of inflammatory immune activity may contribute to health declines in individuals with PTSD, and treating PTSD symptoms may reduce these risks.