Photic memory for executive brain responses
Photic memory for executive brain responses
复制标题
DOI：
10.1073/pnas.1320005111
复制
发表时间：
2014-04-22
影响因子：
11.1
通讯作者：
Vandewalle, Gilles
中科院分区：
文献类型：
--
作者：
Chellappa, Sarah Laxhmi;Ly, Julien Q. M.;Vandewalle, Gilles
光对人类的警觉性和认知力是一种强大的刺激剂，据推测，光是通过严重依赖光色素黑色素的光接收系统起作用的。在人类中，黑色素参与光驱动的认知刺激的证据仍然是间接的，因为很难有选择地分离它的作用。因此，黑素在人类认知调节中的作用仍有待确定。在这里，16名参与者接受了连续且相同的功能磁共振记录，在此期间，他们执行了简单的听觉检测任务和更困难的听觉工作记忆任务，同时持续暴露在相同的测试光(515 Nm)下。我们表明，测试光对执行大脑反应的影响取决于个体在每次记录之前所暴露的光的波长。当参与者在超过1小时前暴露在更长(589 Nm)而不是更短(461 Nm)的波长光中时，测试光对广泛的前额叶区域和枕部执行反应的影响会增加。这种先前光暴露的波长依赖的影响与最近关于光驱动的黑色素双态的理论是一致的。我们的结果强调了光对认知大脑反应的关键作用，是迄今为止支持黑色素认知作用的最强有力的证据，黑素可能赋予人类认知大脑功能一种形式的“光记忆”。
Light is a powerful stimulant for human alertness and cognition, presumably acting through a photoreception system that heavily relies on the photopigment melanopsin. In humans, evidence for melanopsin involvement in light-driven cognitive stimulation remains indirect, due to the difficulty to selectively isolate its contribution. Therefore, a role for melanopsin in human cognitive regulation remains to be established. Here, sixteen participants underwent consecutive and identical functional MRI recordings, during which they performed a simple auditory detection task and a more difficult auditory working memory task, while continuously exposed to the same test light (515 nm). We show that the impact of test light on executive brain responses depends on the wavelength of the light to which individuals were exposed prior to each recording. Test-light impact on executive responses in widespread prefrontal areas and in the pulvinar increased when the participants had been exposed to longer (589 nm), but not shorter (461 nm), wavelength light, more than 1 h before. This wavelength-dependent impact of prior light exposure is consistent with recent theories of the light-driven melanopsin dual states. Our results emphasize the critical role of light for cognitive brain responses and are, to date, the strongest evidence in favor of a cognitive role for melanopsin, which may confer a form of "photic memory" to human cognitive brain function.