Zinc: role in immunity, oxidative stress and chronic inflammation
Zinc: role in immunity, oxidative stress and chronic inflammation
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DOI：
10.1097/mco.0b013e3283312956
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发表时间：
2009-11-01
影响因子：
3.1
通讯作者：
Prasad, Ananda S.
中科院分区：
文献类型：
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作者：
Prasad, Ananda S.
审查目的锌对于包括免疫在内的多种细胞功能至关重要。许多研究人员尝试使用锌补充剂来影响各种疾病的结果。这些努力的目的是通过给予锌来支持免疫力或纠正缺锌个体的锌依赖性免疫功能。最新发现在这篇综述中，介绍了补充锌在各种疾病中的最新发现。补充锌对儿童腹泻、慢性丙型肝炎、志贺氏菌病、麻风病、肺结核、肺炎、急性下呼吸道感染、普通感冒和利什曼病具有有益的治疗作用。补充锌可以有效降低老年人、镰状细胞病（SCD）患者的感染发生率以及降低儿童呼吸道感染的发生率。补充锌可以预防 25% 患有干性 AMD 的老年人失明。补充锌可有效减少老年人和 SCD 患者的氧化应激和炎性细胞因子（如 TNF-α 和 IL-1 β）的产生。总结补充锌已成功用作多种疾病的治疗和预防剂。锌充当免疫细胞的细胞内信号分子。
Purpose of reviewZinc is essential for multiple cellular functions including immunity. Many investigators have used zinc supplementation in an attempt to affect the outcome of various diseases. These efforts were aimed at either supporting immunity by zinc administration or correcting the zinc dependent immune functions in zinc deficient individuals.Recent findingsIn this review, recent findings of zinc supplementation in various diseases have been presented. Beneficial therapeutic response of zinc supplementation has been observed in the diarrhea of children, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory tract infection, common cold, and leishmaniasis. Zinc supplementation was effective in decreasing incidences of infections in the elderly, in patients with sickle cell disease (SCD) and decreasing incidences of respiratory tract infections in children. Zinc supplementation has prevented blindness in 25% of the elderly individuals with dry type of AMD. Zinc supplementation was effective in decreasing oxidative stress and generation of inflammatory cytokines such as TNF-alpha and IL-1 beta in elderly individuals and patients with SCD.SummaryZinc supplementation has been successfully used as a therapeutic and preventive agent for many conditions. Zinc functions as an intracellular signal molecule for immune cells.