CHOLINERGIC MODULATION OF THE SWIMMERET MOTOR SYSTEM IN CRAYFISH
CHOLINERGIC MODULATION OF THE SWIMMERET MOTOR SYSTEM IN CRAYFISH
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DOI：
10.1152/jn.1993.70.6.2391
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发表时间：
1993-12-01
影响因子：
2.5
通讯作者：
MULLONEY, B
中科院分区：
文献类型：
--
作者：
BRAUN, G;MULLONEY, B
1. 毒蕈碱激动剂匹罗卡平诱导小龙虾腹神经索静息分离制剂中的游动运动模式，并以剂量依赖性方式调节爆发频率。尼古丁在静息分离制剂中没有引起节律性活动，但在活性制剂中增加了爆发频率。尼古丁比匹罗卡平产生更高的爆发频率。乙酰胆碱（ACh）类似物carbachol结合了匹罗卡品和尼古丁的作用。它激活了孤立的静息制剂，并像尼古丁一样有效地增加了爆发频率。乙酰胆碱酯酶抑制剂eserine也增加了活性制剂的破裂频率。4. 毒蕈碱和烟碱拮抗剂都不会破坏直泌素诱导的运动模式，这表明直泌素和胆碱能激动剂影响游泳系统激活的两种不同途径。5. 我们得出结论，胆碱能中间神经元参与游泳运动模式的启动，并可以调节其爆发频率。
1. The muscarinic agonist pilocarpine induced the swimmeret motor pattern in resting isolated preparations of the crayfish abdominal nerve cord and modulated the burst frequency in a dose-dependent manner.2. Nicotine did not elicit rhythmic activity in resting isolated preparations but increased the burst frequency in active preparations. Nicotine produced higher burst frequencies than pilocarpine.3. The acetylcholine (ACh) analogue carbachol combined the effects of pilocarpine and nicotine. It activated isolated resting preparations and increased the burst frequency as effectively as nicotine. The ACh-esterase inhibitor eserine also increased the burst frequency in active preparations. 4. Neither muscarinic nor nicotinic antagonists disrupted the proctolin-induced motor pattern, suggesting that proctolin and cholinergic agonists affect two different pathways for the activation of the swimmeret system. 5. We conclude that cholinergic interneurons participate in initiation of the swimmeret motor pattern and can modulate its burst frequency.