Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task
Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task
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DOI：
10.1016/s0166-4328(01)00204-2
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发表时间：
2001-09-14
影响因子：
2.7
通讯作者：
Mizumori, SJY
中科院分区：
文献类型：
--
作者：
Pratt, WE;Mizumori, SJY
本研究在大鼠不同奖赏的八臂放射状迷宫上进行多项记忆测试时，对内侧前额叶皮质(MPFC)的前额叶和下缘神经元在奖赏和空间信息整合中的作用进行了电生理学研究。交替的手臂始终持有两种不同奖励金额中的一种。与以前对大鼠mPFC的检查类似，很少有细胞在延迟期内显示离散的位置场或改变放电。最常见的行为关联是在手臂末端获得奖励之前神经元放电率的变化。少数奖赏相关细胞在高奖赏臂和低奖赏臂之间分化。根据空间环境信息预测预期奖励结果的神经元的存在，与mPFC是融合空间信息及其动机意义的神经系统的一部分的假设是一致的。(C)2001年爱思唯尔科学公司。版权所有。
The present study electrophysiologically examined the contribution of prelimbic and infralimbic neurons in the medial prefrontal cortex (mPFC) to integration of reward and spatial information while rats performed multiple memory trials on a differentially rewarded eight arm radial maze. Alternate arms consistently held one of two different reward amounts. Similar to previous examinations of the rat mPFC, few cells showed discrete place fields or altered firing during a delay period. The most common behavioral correlate was a change in neuronal firing rate prior to reward acquisition at arm ends. A small number of reward-related cells differentiated between high and low reward arms. The presence of neurons that anticipate expected reward consequences based on information about the spatial environment is consistent with the hypothesis that the mPFC is part of a neural system which merges spatial information with its motivational significance. (C) 2001 Elsevier Science B.V.. All rights reserved.