A new process for multicomponent continuous separation by combining multiple liquid chromatography columns
A new process for multicomponent continuous separation by combining multiple liquid chromatography columns
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组合多液相色谱柱多组分连续分离新工艺
DOI：
10.1252/jcej.25.78
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发表时间：
1992
影响因子：
0.8
通讯作者：
M. Ishida
中科院分区：
文献类型：
--
作者：
T. Hatanaka;M. Ishida
模拟移动床吸附器是一种使液相色谱连续化的方法。该方法仅适用于双组分混合物。提出了一种多柱液相色谱联用分离多组分的新方法。它的适用性被证实部分通过实验与一个单一的柱在该过程中，部分通过模拟邻苯二甲酸二甲酯，邻苯二甲酸二乙酯，邻苯二甲酸二正丁酯的分离。结果表明，该工艺可对三种以上组分的混合物进行分离和精制。模拟所需的每个组分的分配系数和总传质系数的值从脉冲响应实验获得，使用相同的柱。
As a method for making liquid chromatography a continuous operation, a simulated moving-bed adsorber has been applied. This method is applicable only to two-component mixtures. Hence a new process for multi-component separation by combining multiple liquid chromatography columns was proposed. Its applicability was confirmed partly by experiments with a single column in the process and partly by simulation of the separation of dimethyl phthalate, diethyl phthalate, and di-n-butyl phthalate. The results showed that a mixture of more than three components can be separated and refined by use of this process. The values of distribution coefficient and overall mass transfer coefficient for each component required for the simulation were obtained from impulse response experiments, using the same column.