Effect of statins on the mortality and mechanical ventilation duration of acute lung injury patients: a meta-analysis of five randomized controlled trials.
Effect of statins on the mortality and mechanical ventilation duration of acute lung injury patients: a meta-analysis of five randomized controlled trials.
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DOI：
10.5414/cp202340
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发表时间：
2015-11
影响因子：
0.8
通讯作者：
Ping Yang;D. Hong;Jian Chen;Xia Zheng;Xiao-yang Lu;Yongzhong Du;Xing-guo Zhang;Saiping Jiang-Saiping-Jia
中科院分区：
文献类型：
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作者：
Ping Yang;D. Hong;Jian Chen;Xia Zheng;Xiao-yang Lu;Yongzhong Du;Xing-guo Zhang;Saiping Jiang-Saiping-Jia
他汀类药物具有抗炎作用，但其与急性肺损伤（ALI）的关系仍存在争议。因此，我们对所有已发表的随机对照试验（RCT）进行了荟萃分析，旨在总结和评估目前关于他汀类药物在ALI患者中潜在应用的证据。方法：我们通过电子数据库检索了2014年12月10日之前关注他汀类药物与ALI相关结局之间关系的文章。由两名研究者进行文献的纳入、纳入研究的质量评价和数据提取。通过Review manager 5.2和STATA 12.0软件对合格文章进行分析。结果分析了5项随机对照临床试验中1，778例患者的数据。重症监护室（ICU）死亡率无差异（RR=0.88，95% CI=0.63-1.22，p=0.44），住院死亡率（RR=1.00，95% CI=0.85-1.17，p=0.97）和机械通气持续时间（MD=-0.40，95%CI =-1.52-0.71，p=0.48）。结论：根据本荟萃分析总结的大量高质量的已发表临床试验，没有足够的证据支持他汀类药物在ALI患者中的应用。
BACKGROUND Statins have been reported to exert anti-inflammatory effects, but the association between statins and acute lung injury (ALI) remains controversial. Thus, we performed a meta-analysis of all published randomized controlled trials (RCTs) aiming to summarize and evaluate the current evidence about the potential use of statins in ALI patients. METHOD We searched for articles that focused on the association between statins and ALI-related outcomes through electronic databases until December 10th, 2014. The inclusion of articles, quality appraisal of included studies, and data extraction were performed by two investigators. Eligible articles were analyzed by Review manager 5.2 and STATA 12.0 software. RESULTS Data from 1,778 patients in five randomized controlled clinical trials were analyzed. No differences in intensive care unit (ICU) mortality (RR=0.88, 95% CI=0.63-1.22, p=0.44), hospital mortality (RR=1.00, 95% CI=0.85-1.17, p=0.97) and mechanical ventilation duration (MD=-0.40, 95% CI=-1.52-0.71, p=0.48) were observed between the experimental and control groups. CONCLUSIONS According to large and high-quality published clinical trials as also summarized by the present meta-analysis, there is insufficient evidence to support the use of statins in ALI patients.