Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata
Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata
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DOI：
10.1111/jocd.12171
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发表时间：
2016-03-01
影响因子：
2.3
通讯作者：
Saleh, Marwah A.
中科院分区：
文献类型：
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作者：
Fawzi, Marwa M. T.;Mahmoud, Sara B.;Saleh, Marwah A.
背景：雄激素性脱发（AGA）是男性最常见的脱发形式。斑秃（AA）是一种器官特异性自身免疫性疾病。研究发现Dickkopf 1 （DKK-1）是Wnt/-catenin信号通路的一种强效抑制因子，可诱导小鼠原细胞向原细胞转化。此外，体外研究表明，DKK-1在双氢睾酮（DHT）诱导的秃顶中起作用。目的评价AGA和AA患者组织中DKK-1的表达水平，探讨其在这两种疾病中可能的发病机制。方法本研究纳入24例AGA患者、31例AA患者和33例健康对照。对所有参与者进行头皮活检，检测组织DKK-1水平。结果AGA患者组织中DKK-1水平显著高于对照组（P=0.000）， AA患者组织中DKK-1水平显著高于对照组（P=0.001）。此外，AGA患者的这些指标明显高于AA患者（P=0.000）。男性AGA患者的DKK-1高于女性。DKK-1与AGA患者病程呈负相关。总之，本研究通过记录两种头发疾病患者中较高的组织DKK-1水平，提示DKK-1在AGA和AA的发病机制中发挥重要作用，并提示DKK-1可能是这两种头发疾病的有希望的治疗靶点。
BackgroundAndrogenetic alopecia (AGA) is the commonest form of hair loss in men. Alopecia areata (AA) is an organ-specific autoimmune disease. Studies revealed that Dickkopf 1 (DKK-1), a powerful suppressor of the Wnt/-catenin signaling pathway, induced anagen-to-catagen transition in mice. Moreover, invitro studies suggested that DKK-1 played a role in dihydrotestosterone (DHT)-induced balding.AimTo evaluate the tissue levels of DKK-1 in patients with AGA and AA, to assess its possible role as a pathogenetic mechanism in both disorders.MethodsThis study included 24 patients with AGA, 31 patients with AA, and 33 healthy controls. Scalp biopsies were taken from all participants for the detection of tissue DKK-1 levels.ResultsTissue DKK-1 levels were significantly higher in patients with AGA than in controls (P=0.000) as well as in patients with AA than in controls (P=0.001). In addition, they were significantly higher in patients with AGA than in patients with AA (P=0.000). DKK-1 was higher in male than in female patients with AGA. DKK-1 was negatively correlated with disease duration in AGA.ConclusionIn conclusion, this study suggests an important role for DKK-1 in the pathogenesis of AGA and AA through documenting higher tissue DKK-1 levels in patients with both hair disorders compared to controls and suggests that DKK-1 may be a promising therapeutic target for these hair diseases.