Light-emitting Diodes versus Compact Fluorescent Tubes for Phototherapy in Neonatal Jaundice: A Multi-center Randomized Controlled Trial
Light-emitting Diodes versus Compact Fluorescent Tubes for Phototherapy in Neonatal Jaundice: A Multi-center Randomized Controlled Trial
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DOI：
10.1007/s13312-010-0020-7
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发表时间：
2010-02-01
影响因子：
2.3
通讯作者：
Singh, S. N.
中科院分区：
文献类型：
--
作者：
Kumar, Praveen;Murki, Srinivas;Singh, S. N.
目的：评价发光二极管（LED）光疗是否与紧凑型荧光灯管（CFT）光疗一样有效，用于治疗健康足月和晚期早产儿非溶血性黄疸。研究设计：多中心开放标签随机对照试验。设置：四个三级护理新生儿病房。主题：健康足月儿和晚期早产儿非溶血性黄疸。干预：单面LED或CFT光疗。主要结果变量：光疗持续时间。结果：共有272名新生儿随机接受LED（n=1.42）或CFT（n=130）光疗。两组的基线人口统计学和生化变量相似。两组的中位光疗持续时间（IQR）相当（26（22-36）h vs. 25（22-36）h; P=0.44）。在任何时间点，两组接受光疗的新生儿比例相似（对数秩检验，P=0.38）。光疗过程中血清总胆红素（STB）下降率和“光疗失败”发生率也无差异。相等比例的新生儿STB反弹性增加，需要重新开始光疗。副作用是罕见的，可比的两组，包括低温，高温，皮疹皮肤变黑和dehydration.Conclusions：LED和CFT光疗单位是同样有效的非溶血性高胆红素血症的管理在健康的长期和。晚期早产新生儿。
Objective: To evaluate whether light-emitting diode (LED) phototherapy is as efficacious as compact fluorescent tube (CFT) phototherapy for the treatment of non-hemolytic jaundice in healthy term and late preterm neonates.Study design: Multi-centre open-label randomized controlled trial.Setting: Four tertiary care neonatal units. Subjects: Healthy term and late preterm neonates with nonhemolytic jaundice.Intervention: Single-surface LED or CFT phototherapy.Primary-outcome variable: Duration of phototherapy.Results: A total of 272 neonates were randomized to receive LED (n=1.42) or CFT (n=130) phototherapy. The baseline demographic and biochemical variables were similar in the two groups. The median duration of phototherapy (IQR) in the two groups was comparable (26 (22-36) h vs. 25(22-36) h; P=0.44). At any time point, a similar proportion of neonates were under phototherapy in the two groups (log-rank test, (P=0.38). The rate of fall of serum total bilirubin (STB) during phototherapy and the incidence of 'failure of phototherapy' were also not different. An equal proportion of neonates had a rebound increase in STB needing restarting of phototherapy. Side effects were rare, comparable in the two groups and included hypothermia, hyperthermia, rash skin darkening and dehydration.Conclusions: LED and CFT phototherapy units were equally efficacious in the management of non-hemolytic hyperbilirubinemia in healthy term and. late-preterm neonates.