Progesterone and preterm birth prevention: translating clinical trials data into clinical practice
Progesterone and preterm birth prevention: translating clinical trials data into clinical practice
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DOI：
10.1016/j.ajog.2012.03.010
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发表时间：
2012-05-01
影响因子：
9.8
通讯作者：
Berghella, Vincenzo
中科院分区：
文献类型：
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作者：
Berghella, Vincenzo
目的：我们试图提供使用孕激素预防早产（PTB）的循证指南。方法：使用PubMed（美国国家医学图书馆，1983年至2012年2月）出版物，以英语撰写，评估孕激素预防PTB的有效性，确定相关文件，特别是随机试验。评估的孕激素特别是阴道孕酮和17-α-羟基-孕酮己酸酯。此外，还使用了科克伦图书馆、组织指南和通过审查上述内容确定的研究来识别相关文章。根据研究人群对数据进行评价，对单胎与多胎妊娠、既往PTB或经阴道超声宫颈长度（CL）短以及这些因素的组合进行单独分析。与美国预防工作组的建议相一致，参考文献的质量进行了评估的基础上，最高水平的证据，并建议分级。结果和建议：总结随机研究表明，在妇女与单胎妊娠，没有事先PTB，和短期CL
OBJECTIVE: We sought to provide evidence-based guidelines for using progestogens for the prevention of preterm birth (PTB).METHODS: Relevant documents, in particular randomized trials, were identified using PubMed (US National Library of Medicine, 1983 through February 2012) publications, written in English, which evaluate the effectiveness of progestogens for prevention of PTB. Progestogens evaluated were, in particular, vaginal progesterone and 17-alpha-hydroxy-progesterone caproate. Additionally, the Cochrane Library, organizational guidelines, and studies identified through review of the above were utilized to identify relevant articles. Data were evaluated according to population studied, with separate analyses for singleton vs multiple gestations, prior PTB, or short transvaginal ultrasound cervical length (CL), and combinations of these factors. Consistent with US Preventive Task Force suggestions, references were evaluated for quality based on the highest level of evidence, and recommendations were graded.RESULTS AND RECOMMENDATIONS: Summary of randomized studies indicates that in women with singleton gestations, no prior PTB, and short CL