Cell Cycle Progression Determines Wing Morph in the Polyphenic Insect Nilaparvata lugens
Cell Cycle Progression Determines Wing Morph in the Polyphenic Insect Nilaparvata lugens
复制标题
细胞周期进程决定多酚昆虫褐飞虱翅膀的形态
DOI：
10.1016/j.isci.2020.101040
复制
发表时间：
2020-04-24
期刊：
影响因子：
5.8
通讯作者：
Lavine, Laura Corley
中科院分区：
文献类型：
--
作者：
Lin, Xinda;Gao, Han;Lavine, Laura Corley
翅多型是指一个基因型可以产生两个或多个不同的翅表型以适应特定环境的现象。目前尚不清楚的是，翼垫的发育是如何受到内分泌信号（如胰岛素和JNK通路）下游的控制的。我们发现，在细胞增殖，胞质分裂和细胞周期进程的重要基因是必要的长翅膀的生长和发育。翅垫细胞发育的长翅型的特点是高度结构化的上皮层与微绒毛样结构。成虫短翅垫的细胞主要处于细胞周期的G2/M期，而长翅垫的细胞主要处于G1期。我们的研究是第一个报告的比较发育和细胞形态和结构的翅膀变形，并进行全面评估的细胞周期基因的翅膀发展的这种独特的，适应性的生活史策略。
Wing polyphenism is a phenomenon in which one genotype can produce two or more distinct wing phenotypes adapted to the particular environment. What remains unknown is how wing pad development is controlled downstream of endocrine signals such as insulin and JNK pathways. We show that genes important in cellular proliferation, cytokinesis, and cell cycle progression are necessary for growth and development of long wings. Wing pad cellular development of the long-winged morph was characterized by a highly structured epithelial layer with microvilli-like structures. Cells of adult short wing pads are largely in the G2/M phase of the cell cycle, whereas those of long wings are largely in G1. Our study is the first to report the comparative developmental and cellular morphology and structure of the wing morphs and to undertake a comprehensive evaluation of the cell cycle genes necessary for wing development of this unique, adaptive life history strategy.