Electronic and Ionic Materials for Neurointerfaces
Electronic and Ionic Materials for Neurointerfaces
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DOI：
10.1002/adfm.201704335
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发表时间：
2018-03-21
影响因子：
19
通讯作者：
Melosh, Nicholas A.
中科院分区：
文献类型：
--
作者：
Ferro, Marc D.;Melosh, Nicholas A.
活体脑组织和工程设备之间的通信是了解大脑功能和恢复疾病，损伤和老年神经功能缺损的关键环节。通过新的材料和设备设计，新一代的大脑接口技术正在取代笨重的系统，提供更低的组织损伤，降低免疫原性和长期稳定性。具有改进的慢性性能和日益强调多模态能力的新电极材料正在集成到超柔性和机械顺应性架构中。随着这些尺寸的缩小和通道数量的增加，双向单细胞界面的目标几乎可以实现。然而，这些系统的有前途的长期可靠性、毒性和性能在很大程度上仍然是未知的。在这里，电极材料和体内技术的基础进行了审查，并在电子和离子材料的最新进展突出。
Communication between living brain tissue and engineered devices is the key link to understand brain function and restore neurological deficits from disease, injury, and old age. Enabled by new materials and device designs, a new generation of brain interface technologies is replacing bulkier systems, offering lower tissue damage, reduced immunogenicity, and long-term stability. New electrode materials with improved chronic performance and increasing emphasis on multimodal capabilities are being integrated onto ultraflexible and mechanically compliant architectures. As these scale to smaller dimensions and higher channel counts, the goal of bidirectional, single-cell interfaces is nearly within reach. However, promising, long-term reliability, toxicity, and performance of these systems are still largely unknown. Here, the basics of electrode materials and in vivo technologies are reviewed, and recent advances in electronic and ionic materials are highlighted.