INVITRO RESPONSIVENESS OF HUMAN ASTHMATIC BRONCHUS TO CARBACHOL, HISTAMINE, BETA-ADRENOCEPTOR AGONISTS AND THEOPHYLLINE
INVITRO RESPONSIVENESS OF HUMAN ASTHMATIC BRONCHUS TO CARBACHOL, HISTAMINE, BETA-ADRENOCEPTOR AGONISTS AND THEOPHYLLINE
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DOI：
10.1111/j.1365-2125.1986.tb02956.x
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发表时间：
1986-12-01
影响因子：
3.4
通讯作者：
PATERSON, JW
中科院分区：
文献类型：
--
作者：
GOLDIE, RG;SPINA, D;PATERSON, JW
1在人死后3-15小时的正常肺和哮喘肺标本中，测定了人支气管条对收缩和舒张激动剂的反应。2卡巴胆碱和组胺的效力在哮喘中比在非病变支气管中低约两倍。卡巴胆碱组有显著性差异（P < 0.05），组胺组无显著性差异（P > 0.05）。这些结果清楚地表明，在哮喘中观察到的支气管对气道痉挛原的高反应性完全是一种体内现象，不涉及支气管平滑肌敏感性的增加。3. β的效力-肾上腺素受体激动剂异丙肾上腺素、非诺特罗和特布他林在哮喘支气管中与非患病气道相比显著降低4-5倍。与此相反，茶碱是等效的两个群体的气道制剂。因此，看来严重哮喘与支气管平滑肌β 2-肾上腺素受体功能降低有关。
1 Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. 2 The potencies of carbachol and histamine were approximately two times less in asthmatic than in non-diseased bronchi. This was statistically significant for carbachol (P < 0.05), but not for histamine (P > 0.05). These results clearly indicate that the bronchial hyperreactivity to airway spasmogens observed in asthma is exclusively an in vivo phenomenon not involving increasing sensitivity of bronchial smooth muscle. 3 The potencies of the .beta.-adrenoceptor agonists isoprenaline, fenoterol and terbutaline were significantly reduced by 4-5 fold in asthmatic bronchi compared with non-diseased airways. In contrast, theophylline was equipotent in the two populations of airway preparations. Thus, it appears that severe asthma is associated with decreased bronchial smooth muscle .beta.2-adrenoceptor function.