Multiple Myeloma and Hairy Cell Leukemia: A Rare Association or Coincidence?
Multiple Myeloma and Hairy Cell Leukemia: A Rare Association or Coincidence?
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多发性骨髓瘤和毛细胞白血病：罕见的关联还是巧合？
DOI：
10.3109/10428190109097724
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发表时间：
2001
影响因子：
2.6
通讯作者：
B. Greenberg
中科院分区：
文献类型：
--
作者：
M. Saif;B. Greenberg
毛细胞白血病（HCL）和多发性骨髓瘤（MM）是具有独特临床和病理特征的明确定义的实体。尽管大多数HCL和MM病例符合其经典描述，但最近的研究表明，它们的临床和形态学边界不仅可能重叠，而且还可能发生HCL向MM的转化。我们报告另一个病例的HCL其次是发展的MM后9年。他还开发了他的右踝关节积血的时候，MM的诊断。从骨髓穿刺提取的DNA的PCR分析是阴性的单克隆重排的免疫球蛋白重链基因的存在。免疫表型显示无HCL证据。HCL患者发生MM有几种可能的解释，例如不同疾病实体的共存或单一疾病实体的不同临床和形态学阶段。HCL或MM的准确诊断至关重要，因为它们的治疗方法不同。该患者的关节积血也可能是MM的首次表现，MM的一个特征很少报告。
Hairy cell leukemia (HCL) and multiple myeloma (MM) are well-defined entities with distinctive clinical and pathological features. Although most cases of HCL and MM fit their classic descriptions, more recent studies have revealed that their clinical and morphological boundaries may not only overlap but a transformation of HCL into MM could also occur. We report another case of HCL followed by the development of MM after 9 years. He also developed hemarthrosis of his right ankle at the time of diagnosis of MM. PCR analysis of DNA extracted from the bone marrow aspirate was negative for the presence of a monoclonally rearranged immunoglobulin heavy chain gene. Immunophenoytping revealed no evidence of HCL. There are several possible explanations for the development of MM in HCL patients, such as the coexistence of separate disease entities or different clinical and morphologic phases of a single disease entity. An accurate diagnosis of HCL or MM is critical because of differences in their treatment. Hemarthrosis in this patient may also have been the first manifestation of MM, a feature of MM which has rarely been reported.
抗酒石酸盐酸性磷酸酶的细胞化学：15 年经验。
影响因子：
11.4
作者：
Yam,LT;Janckila,AJ;Li,CY;Lam,WK
通讯作者：
Lam,WK
毛细胞白血病：前浆细胞肿瘤。
影响因子：
20.3
作者：
Anderson,KC;Boyd,AW;Fisher,DC;Leslie,D;Schlossman,SF;Nadler,LM
通讯作者：
Nadler,LM