Structure of the primate oculomotor burst generator. II. Medium-lead burst neurons with downward on-directions.
Structure of the primate oculomotor burst generator. II. Medium-lead burst neurons with downward on-directions.
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灵长类动眼神经爆发发生器的结构。
DOI：
10.1152/jn.1991.65.2.218
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发表时间：
1991
影响因子：
2.5
通讯作者：
Warren,JD
中科院分区：
文献类型：
--
作者：
Moschovakis,AK;Scudder,CA;Highstein,SM;Warren,JD
1.为了研究垂直向下中导联爆发式神经元的形态和生理学，我们通过穿透中脑轴突，记录了与警觉、行为正常的松鼠猴的自发眼跳有关的放电模式。将选定的轴突注射辣根过氧化物酶，并对其进行形态特征观察。2.DMLB发出的脉冲比眼球的快速运动早大约5毫秒。眼球跳动参数(眼球向下移位的持续时间和幅度)与猝发参数(棘波持续时间和数目)高度相关。3.DMLB胞体位于内侧纵束头端间质核(RiMLF，n=14)和Cajal间质核(NIC，n=2)。来自rMLF DMLB的纤维投射到NIC以及动眼复合体的下直肌和上斜肌。NIC DMLB的轴突投射到同侧的RiMLF、NIC和中脑网状结构，但不投射到动眼复合体。4.我们的数据表明，一些DMLB可以为双眼的眼外运动神经元提供它们在向下扫视时所显示的活动脉冲。此外，这样的神经元可以向NIC提供这个核团被认为整合的信号之一，以提取对垂直眼睛位置的估计。最后，我们的数据证明了DMLB的存在，这些DMLB不与动眼神经建立直接联系。
1. To investigate the morphology and physiology of vertical medium-lead burst neurons with downward on-directions (DMLBs), we impaled midbrain axons and recorded their discharge patterns in relation to spontaneous saccades of alert, behaving squirrel monkeys. Selected axons were injected with horseradish peroxidase and morphologically characterized. 2. DMLBs emitted bursts of impulses that preceded rapid eye movements by approximately 5 ms. Parameters of the burst (duration and number of spikes) were highly correlated with parameters of the saccadic eye movement (duration and amplitude of the downward displacement of the eyes). 3. Somata of DMLBs were recovered in the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF, n = 14), and in the interstitial nucleus of Cajal (NIC, n = 2). Fibers originating from riMLF DMLBs projected, usually ipsilaterally, to the NIC as well as in the inferior rectus and the superior oblique subdivisions of the oculomotor complex. The axons of NIC DMLBs projected to the ipsilateral riMLF, NIC, and the mesencephalic reticular formation but not to the oculomotor complex. 4. Our data demonstrate that some DMLBs can provide extraocular motoneurons of both eyes with the pulse of activity they display during downward saccades. In addition, such neurons can supply the NIC with one of the signals that this nucleus is thought to integrate to extract an estimate of the vertical eye position. Finally, our data demonstrate the existence of DMLBs that do not establish direct connections with oculomotoneurons.