Central orexin-A augments sympathoadrenal outflow in conscious rabbits
Central orexin-A augments sympathoadrenal outflow in conscious rabbits
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DOI：
10.1161/01.hyp.37.6.1382
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发表时间：
2001-06-01
期刊：
影响因子：
8.3
通讯作者：
Abe, I
中科院分区：
文献类型：
--
作者：
Matsumura, K;Tsuchihashi, T;Abe, I
我们确定了清醒家兔脑室内给药食欲素-A的心血管和神经激素反应。侧脑室注射食欲素A引起平均动脉压和肾交感神经活动的剂量相关性增加。通过脑室内注射100 pmol食欲素-A诱导的平均动脉压和肾交感神经活性的峰值（分别为14.0 +/-0.7 mm Hg和55.4 +/-14.9%）分别在注射后40和25分钟获得。侧脑室注射食欲素-A后60和90分钟血浆肾上腺素和葡萄糖浓度显著升高（对照组对90分钟;肾上腺素38.0 ± 12.8对167.5 ± 42.5 pg/mL，P
We determined the cardiovascular and neurohormonal responses to intracerebroventricular administration of orexin-A in conscious rabbits. Intracerebroventricular injection of orexin-A elicited dose-related increases in mean arterial pressure and renal sympathetic nerve activity. Peak values of mean arterial pressure and renal sympathetic nerve activity induced by intracerebroventricular injection of 100 pmol of orexin-A (14.0 +/-0.7 mm Hg and 55.4 +/- 14.9%, respectively) were obtained at 40 and 25 minutes after injection, respectively. Plasma epinephrine and glucose concentrations were significantly increased at 60 and 90 minutes after intracerebroventricular injection of orexin-A (control versus 90 minutes; for epinephrine, 38.0 +/- 12.8 versus 167.5 +/- 42.5 pg/mL, P