Long-term outcomes after invasive breast tumor recurrence (IBTR) in women with DCIS in NSABP B-17 and B-24
Long-term outcomes after invasive breast tumor recurrence (IBTR) in women with DCIS in NSABP B-17 and B-24
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NSABP B-17 和 B-24 中患有 DCIS 的女性浸润性乳腺肿瘤复发 (IBTR) 后的长期结果
DOI：
10.1200/jco.2007.25.18_suppl.520
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
N. Wolmark
中科院分区：
文献类型：
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作者：
I. Wapnir;J. Dignam;T. Julian;S. Land;E. Mamounas;S. Anderson;V. Fourchotte;J. Costantino;N. Wolmark
背景：DCIS患者接受肿块切除术治疗有非常好的结果，但存在IBTR的风险。局部控制是改善放疗（RT）和辅助他莫昔芬（TAM）。局部失败，特别是侵入性IBTR（I-IBTR），可能会影响长期结局。我们从两个NSABP随机试验的DCIS患者队列中获得长期结果。患者和方法：共纳入NSABP B-17和B-24（1985年至1994年随机分配）的2,615例原发性DCIS女性。中位随访时间> 12年。在B-17中，治疗是乳房肿瘤切除术（LO，403）或乳房肿瘤切除术加全乳放疗（LRT，410）。在B-24例患者接受LRT（901）或LRT + TAM [901]。按治疗检查IBTR的风险比和累积发生率。评价了与既往IBTR相关的死亡率风险。结果：465例患者（243例侵入性，222例非侵入性）IBTR首次失败。所有IBTR的12年累积发生率为LO 32.9%、LRT 15.8%和LRT+TAM 12.5%。RT signa...
520 Background: DCIS patients treated with lumpectomy have a very favorable outcome but are at risk for IBTR. Local control is improved by radiotherapy (RT) and adjuvant tamoxifen (TAM). Local failures, specifically invasive IBTRs (I-IBTR), may impact on long-term outcome. We present long-term outcome results from a cohort of DCIS patients from two NSABP randomized trials. Patients and Methods: A total of 2,615 women with primary DCIS from NSABP B-17 and B-24 (randomized from 1985 to 1994) were included. Median follow-up was > 12 yrs. In B-17 treatment was lumpectomy (LO, 403) or lumpectomy with whole breast irradiation (LRT, 410). In B-24 patients received LRT (901) or LRT plus TAM [901]. Hazard ratio and cumulative incidence of IBTR were examined by treatment. Mortality hazard was evaluated in relation to prior IBTR. Results: IBTR was a first failure in 465 patients (243 invasive, 222 noninvasive). The 12 year cumulative incidence of all IBTRs was 32.9% for LO, 15.8% LRT, and 12.5% LRT+TAM. RT significa...