Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study
Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study
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DOI：
10.1016/j.clnu.2010.08.001
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发表时间：
2011-04-01
影响因子：
6.3
通讯作者：
Negi, Mahendra Pal Singh
中科院分区：
文献类型：
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作者：
Tiwari, Amit Kumar Mani;Mahdi, Abbas Ali;Negi, Mahendra Pal Singh
背景与目的：本研究旨在评价补充铁(100 mg/d)和叶酸(500 mg/d)对缺铁性贫血妇女的有利和不良影响。方法：对117例贫血妇女(轻度55例，中度40例，重度22例)和60例年龄匹配的安慰剂(100 mg蔗糖)非贫血对照组进行100天的铁和叶酸补充。结果：治疗后贫血妇女血红蛋白(Hb)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽还原酶(GSH-RD)、还原型谷胱甘肽(GSH)和总抗氧化能力(TAC)均显著升高(P<0.01)。而谷胱甘肽过氧化物酶(GSH-Px)和抗氧化性维生素A、C、E在各处理组均显著降低(P<；0.01)。口服补铁组大鼠血清过氧化脂质(LPO)、蛋白质羰基(PC)、共轭双烯(CD)、过氧化脂质(LOOH)和氧化谷胱甘肽(GSSG)水平显著升高(P<0.01)。此外，与中度和重度贫血组相比，轻度补铁的不良副作用最大，而恶心、呕吐和全身反应在所有接受治疗的受试者中可以忽略不计。结论：研究发现推荐剂量的补铁有效改善Hb，但代价是氧化应激增加(轻度和中度；重度)。建议避免盲目补铁，应根据需要提供补铁。(C)2010年爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 mu g/day) supplementation in iron deficient anemic women.Methods: Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols.Results: Haemoglobin (Hb) levels along with antioxidant enzymes, namely catalase, superoxide dismutase (SOD), glutathione reductase (GSH-Rd), reduced glutathione (GSH) and total antioxidant capacity (TAC) were found significantly increased (P < 0.01) in anemic women after treatment. However, the glutathione peroxidase (GSH-Px) and antioxidant vitamins A. C and E were found significantly decreased (P < 0.01) in all treated groups. Lipid peroxide levels (LPO), protein carbonyl (PC), conjugated dienes (CD), lipid hydroperoxide (LOOH) and oxidized glutathione (GSSG) levels were found significantly increased (P < 0.01) after oral iron supplementation groups. Moreover, undesirable side effects of iron supplementation were observed maximally in mild as compared with moderate and severe anemic groups, whereas nausea, vomiting, systemic reactions were negligible in all treated subjects.Conclusion: Study found recommended dose of iron effective for improving Hb, but at the cost of increased oxidative stress (mild > moderate > severe). It is suggested that blind iron supplementation should be avoided and shall be provided on need basis. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.