A beginner's guide to NF-κB signaling pathways
A beginner's guide to NF-κB signaling pathways
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DOI：
10.1196/annals.1329.002
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Diederich, M
中科院分区：
文献类型：
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作者：
Delhalle, S;Blasius, R;Diederich, M
核因子-KB是异源二聚体转录因子家族的一员，在炎症和应激反应以及肿瘤细胞对凋亡的抵抗中起着关键作用。这些效应是由于许多促炎症和抗凋亡基因依赖于核因子-KB的转录，这些基因的产物确保了细胞对环境条件的各种反应。导致核因子-KB激活的信号转导通路被很好地描述，这些通路中涉及的不同步骤涉及到可以构成核因子-KB抑制靶点的蛋白质。研究了几种旨在阻止核因子-KB活性从而阻止靶基因转录的抑制剂，其中几种化合物似乎特别有希望。我们在这里试图总结出各种关于核因子-KB的研究所能带来的优势。
Nuclear factor KB (NF-KB) belongs to a family of heterodimeric transcription factors that play a key role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis. These effects are due to the NF-KB-dependent transcription of many proinflammatory and antiapoptotic genes, whose products ensure various cell responses to environmental conditions. The signal transduction pathways leading to NF-KB activation are well characterized, and the different steps implicated in these pathways involve proteins that could constitute targets for NF-KB inhibition. Several inhibitors aiming to prevent NF-KB activity and thus the transcription of target genes are studied, and a few compounds seem particularly promising. We try here to summarize the advantages that can issue from various studies on NF-KB.