PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis
PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis
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DOI：
10.1007/s10238-013-0271-4
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发表时间：
2015-02-01
影响因子：
4.6
通讯作者：
Jin, Eun-Jung
中科院分区：
文献类型：
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作者：
Song, Jinsoo;Kim, Dongkyun;Jin, Eun-Jung
尽管长链非编码RNA（lncRNA）在正常生理和疾病条件下的重要性日益增加，但我们对RA相关lncRNA的了解仍然有限。因此，我们的目的是确定lncRNA的签名，在RA的预后价值。类风湿关节炎（RA）患者外周血单个核细胞和血清外泌体中Hotair的表达水平显著增高，导致活性巨噬细胞迁移。相反，在分化的破骨细胞和类风湿性滑膜细胞中检测到明显较低水平的Hotair，并且Hotair的增强表达导致MMP-2和MMP-13的水平显著降低。本研究为Hotair可能成为诊断类风湿关节炎的潜在生物标志物提供了新的经验证据。
Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.