Crystalglobulin‐induced vasculopathy accompanying ischemic intestinal lesions of a patient with myeloma
Crystalglobulin‐induced vasculopathy accompanying ischemic intestinal lesions of a patient with myeloma
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骨髓瘤患者伴有肠道缺血性病变的晶体球蛋白诱导血管病变
DOI：
10.1111/j.1440-1827.1996.tb03594.x
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发表时间：
1996
影响因子：
2.2
通讯作者：
M. Naito
中科院分区：
文献类型：
--
作者：
H. Usuda;I. Emura;M. Naito
1例37岁多发性骨髓瘤(λ)患者出现小肠穿孔和足部坏疽。在切除的小肠和膝下截肢的足部，可见血管内晶体沉积，免疫组织化学显示免疫球蛋白G呈阳性，并有一条轻链。尽管浆细胞异型增生过程中产生的副蛋白可能结晶并导致全身性闭塞性血管病变，但这是首例肠道受累。因为这位患者没有冷球蛋白血症，所以晶体可能来自骨髓瘤蛋白，骨髓瘤蛋白有时在血液中结晶而不受低温的影响。
A 37 year old man with multiple myeloma (IgGλ) developed perforation of the small Intestine and had gangrene In his feet. In the resected small intestine and below‐knee amputated feet, intravascular deposition of crystals, Immunohlsto‐chemically positive for IgG and a lambda light chain, were found. Although paraproteins produced in the course of plasma cell dyscrasia may crystallize and cause systemic occlusive vasculopathy, this is the first case with intestinal involvement. Because cryoglobulinemia was absent in this patient, crystals may be derived from the myeloma protein which sometimes crystallizes In the blood without the Influence of low temperature.