Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I-III from Curcuma longa
Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I-III from Curcuma longa
复制标题
DOI：
10.1016/s0944-7113(00)80048-3
复制
发表时间：
2000-07-01
期刊：
影响因子：
7.9
通讯作者：
Nair, MG
中科院分区：
文献类型：
--
作者：
Ramsewak, RS;DeWitt, DL;Nair, MG
测定了姜黄素I、姜黄素II(单去甲氧基姜黄素)和姜黄素III(双去甲氧基姜黄素)的细胞毒性、抗氧化和抗炎活性。这些化合物显示出对白血病、结肠癌、中枢神经系统、黑色素瘤、肾脏和乳腺癌细胞株的活性。100微克/毫升姜黄素I-III对脂质体过氧化的抑制率分别为58%、40%和22%。观察姜黄素对COX-I和COX-II酶的抑制作用。姜黄素I-III在125mU g/ml时对COX-I酶有抑制作用，其抑制率分别为32%、38.5%和39.2%。125 mg/ml的姜黄素I-III对COX-II酶也有较好的抑制作用，分别为89.7%、82.5%和58.9%。
Curcumin I, curcumin II (monodemethoxycurcumin) and curcumin III (bisdemethoxycurcumin) from Curcuma longa were assayed for their cytotoxicity, antioxidant and anti-inflammatory activities. These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines. The inhibition of liposome peroxidation by curcumins I-III at 100 mu g/ml were 58, 40 and 22%, respectively. The inhibition of COX-I and COX-II enzymes by the curcumins was observed. Curcumins I-III were active against COX-I enzyme at 125 mu g/ml and showed 32, 38.5 and 39.2% inhibition of the enzyme, respectively. Curcumins I-III also showed good inhibition of the COX-II enzyme at 125 mg/ml with 89.7, 82.5 and 58.9% inhibition of the enzyme, respectively.